微血管密度和细胞周期调控蛋白B1表达与鼻咽癌放射敏感性的关系  

Microvascular-density and cell cycle regulation protein B1 and the radiotherapy sensitvity of nasopharyngeal carcinoma

作　　者：高力英[1] 王小虎[1] 杨生兰 赵林[1] 张秋宁[1] 蔡宏懿[1] 

机构地区：[1]甘肃省肿瘤医院放疗科,甘肃兰州730050 [2]兰州石化总医院,甘肃兰州730060

出　　处：《现代肿瘤医学》2010年第4期679-682,共4页Journal of Modern Oncology

基　　金：甘肃省科学事业费计划项目(编号QS061-C33-01)

摘　　要：目的:探讨微血管密度、细胞周期蛋白B1与放射治疗前后鼻咽癌肿瘤体积的关系。方法:对76例病理证实的鼻咽癌患者放疗前鼻咽活检组织进行MVD、CyclinB1免疫组化染色,在50Gy、70Gy、放疗结束后6个月行增强CT扫描,计算肿瘤体积,用SPSS10.0统计软件进行Spearman等级相关分析及偏相关分析。结果:ClydinB1表达与V50/V0,V70,V6m的关系:与V50/V0P=0.036;与V70P=0.199;与V6mP=0.142。MVD表达与V50/V0,V70,V6m的关系:与V50/V0P=0.036;与V70P=0.199;与V6mP=0.142。ClydinB1表达与MVD关系:P=0.000。结论:微血管的生成是鼻咽癌生长的关键,它的高低与临床放射敏感性密切相关。CyclinB1与临床放射敏感性指标V50/V0(肿瘤退缩率)密切相关。ClydinB1与MVD密切相关。Objective：To study the relation between microvascular-density（MVD）,cell cycle protein B1 this M,G2 period cells with radiotherapy of nasopharyngeal carcinoma patients.Methods： For 77 cases of pathologically proven nasopharyngeal carcinoma patients before radiotherapy CyclinB1 and MVD were tested by immunohistochemical methad.Results： ClydinB1 expression and V50/V0,V70,V6m relations ：V50/V0 P=0.036;V70 P=0.119,V6m P=0.142,V50/V0 MVD expression and V70,V6m,V50/V0 P=0.036;V70 P=0.119,V6m P=0.142.ClydinB1 MVD expression P=0.000.Conclusion： Microvascular density of nasopharyngeal carcinoma is closely related with clinical radiation sensitivity.CyclinB1 and clinical radiation sensitivity index V50/V0 are closely related.

关 键 词：鼻咽癌 放射敏感性 细胞周期蛋白 微血管密度 肿瘤体积 

分 类 号：R739.62[医药卫生—肿瘤]