FHIT基因及其与食管癌关系的研究进展  

The study on the correlation between FHIT gene and esophageal carcinoma

作　　者：安琪[1] 张丽英[1] 叶菁[1] 李青[1] 

机构地区：[1]第四军医大学病理学教研室,陕西西安710032

出　　处：《现代肿瘤医学》2010年第4期825-827,共3页Journal of Modern Oncology

摘　　要：脆性组氨酸三联体(FHIT)基因是一个候选抑癌基因,其抑癌作用可能通过诱导凋亡而实现。在多种肿瘤特别是环境致癌物引起的肿瘤中常有FHIT基因的异常改变。FHIT基因可能通过调控细胞周期,诱导细胞凋亡发挥抑制肿瘤的作用,其失活机制主要表现为启动子区域CPG岛甲基化、缺失及异常转录。此文拟就FHIT基因与食管癌的发生、发展、治疗及预后等几方面进行综述。Fragile histidine triad（FHIT） gene is a candidate tumor suppressor gene,the suppressor may be achieved through the induction of apoptosis.In a variety of tumors in particular,environmental carcinogens are often caused by tumors of the FHIT gene abnormalities.FHIT gene may control the cell cycle,apoptosis induced by tumor play a role in the mechanism of its inactivation is mainly expressed in the promoter region of CPG island methylation,deletion and abnormal transcription.The article witl introduce the FHIT gene and the occurrence of esophageal cancer,development,treatment and prognosis and other aspects were reviewed.

关 键 词：FHIT基因 抑癌基因 食管癌 

分 类 号：R735.1[医药卫生—肿瘤]