STAT3在人喉鳞状细胞癌中的表达及意义  

Expression and significance of STAT3 in laryngeal squamous cell cancer

作　　者：富东娜[1] 文连姬[2] 高丽芳[3] 赵胤[2] 王淑英[1] 冯丽[1] 齐晓丹[1] 

机构地区：[1]齐齐哈尔医学院生物化学与分子生物学教研室,黑龙江齐齐哈尔161006 [2]吉林大学第二医院耳鼻咽喉科,吉林长春130041 [3]吉林心脏病医院,吉林长春130062

出　　处：《癌变．畸变．突变》2010年第2期112-114,118,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：目的:研究信号转导与转录活化因子3(signal transducers and activators of transcription 3,STAT3)在人喉鳞状细胞癌(简称喉癌)组织中的表达,探讨其在喉癌发生发展中的作用。方法:应用免疫组化SP法检测12例正常喉组织及38例喉癌组织中STAT3的阳性表达情况。结果:STAT3阳性表达主要定位于细胞浆,STAT3蛋白在喉癌组织中的阳性细胞表达率(44.05%±13.82%)高于正常喉黏膜组织(6.40%±1.77%),其差异具有统计学意义(P<0.01)。中、低分化伴颈部淋巴结转移的喉癌组织中STAT3阳性细胞表达率显著高于高分化、无颈部淋巴结转移的喉癌组织(P<0.05)。结论:STAT3在喉癌组织的高表达可能与喉癌的发生、发展密切相关。OBJECTIVE：To explore the expression and significance of signal transducers and activators of transcription 3（STAT3） in laryngeal squamous cell cancer. METHODS： Immunohistochemical technique was used to examine expression of STAT3 in 12 normal tissues and 38 laryngeal cancer. RESULTS： Positive staining of STAT3 was localized in the cytoplasm. The positive rate of STAT3 in 38 laryngeal cancer was significantly higher than those in 12 normal tissues（P0.01）. Overexpression of STAT3 protein was tested in those cancers with lymph nodes metastasis（P0.05）, and had a close relationship with histological grades（P0.05）. CONCLUSION： Overexpression of STAT3 might have a close correlation with the development of laryngeal squamous cell carcinoma.

关 键 词：喉肿瘤 癌 信号转导与转录活化因子3 

分 类 号：R739.65[医药卫生—肿瘤]