胃镜活检组织kiss-1基因检测与肿瘤分期及预后的关系  

Relationship of kiss-1 gene expression with the TNM stage and prognosis in gastric cancer

作　　者：徐夏[1] 张志强[1] 关晓军[1] 卢润章[1] 吴丹西[1] 郑丹 

机构地区：[1]哈尔滨市第一医院血液病肿瘤研究所,黑龙江省哈尔滨市150010 [2]哈尔滨市红十字医院妇产科,黑龙江省哈尔滨市150010

出　　处：《世界华人消化杂志》2010年第7期726-729,共4页World Chinese Journal of Digestology

基　　金：哈尔滨市科技创新人才研究专项基金资助项目;No.RC2008RFQQS078~~

摘　　要：目的:研究kiss-1基因在胃癌中的表达水平及其临床意义.方法:30例患者依照PCR技术检测出的kiss-1表达中位数分为高表达和低表达2组,对比临床病理学特征.结果:kiss-1基因低表达者较高表达者均伴有低肿瘤分期(t=1.87,F=1.00,P=0.025)、频发肿瘤周围静脉侵袭(t=3.51,F=1.22,P=0.009)和远处淋巴结转移(t=2.26,F=2.17,P=0.009).结论:kiss-1基因表达可以成为反映胃癌分期和预后的重要生物学标志物.AIM： To investigate the clinical value of the expression of kiss-1 （a metastasis suppressor gene） in gastric cancer. METHODS： The expression of kiss-1 mRNA in gastroscopic biopy specimens taken from 30 gastric cancer patients was detected by reverse transcription-polymerase chain reaction. Based on kiss-1 expression level, the patients were divided into two groups： those with high and low expression of kiss-1 mRNA. The clinicopathologic characteristics of gastric cancer were thencompared between the two groups. RESULTS： The expression levels of kiss-1 mRNA in stage III-IV （TNM） gastric cancer patients （t = 1.87, F = 1.00, P = 0.025） and those with frequent venous invasion （t = 3.51, F = 1.22, P = 0.009） or frequent distant lymph node metastasis （t = 2.26, F = 2.17, P = 0.009） were significantly lower than those in stage I-II （TNM） gastric cancer patients and those without venous invasion or distant lymph node metastasis, respectively. CONCLUSION： The expression level of kiss-1 mRNA can be used as an important biological marker for evaluating the TNM stage and prognosis of gastric cancer.

关 键 词：KISS-1 胃镜 肿瘤分期 预后 

分 类 号：R730.4[医药卫生—肿瘤]