18例骨外Ewing肉瘤的临床分析并文献复习  

Extraskeletal Ewing's sarcoma:a report of 18 cases and literature review

作　　者：谢春芳[1,2,3] 刘孟忠[1,2] 习勉[1,2] 

机构地区：[1]华南肿瘤学国家重点实验室,广东广州510060 [2]中山大学肿瘤防治中心放射治疗科,广东广州510060 [3]广东佛山三水区人民医院肿瘤科,广东佛山528100

出　　处：《癌症》2010年第4期462-467,共6页Chinese Journal of Cancer

摘　　要：背景与目的:骨外Ewing肉瘤是指原发于骨组织外的尤文氏肉瘤,发病率低。本研究旨在通过对骨外Ewing肉瘤进行临床分析,探讨其临床特点、诊断和治疗方法。方法:回顾分析中山大学肿瘤防治中心1995年1月～2007年7月确诊并接受治疗的18例骨外Ewing肉瘤患者的临床资料,同时结合文献加以讨论。结果:18例患者中,男性13例,女性5例;年龄8个月～60岁,中位年龄17岁,其中12例患者(66.7%)年龄为5～25岁。肿瘤原发于下肢8例(44.4%),椎旁5例(27.8%),胸壁2例(11.1%)。临床症状表现为肿块16例(88.9%)。16例患者接受了综合治疗,2例接受了非综合治疗。1、3、5年生存率分别为82.4%、64.2%和32.1%。单因素分析显示有无远处转移及治疗模式与预后相关。结论:该肿瘤好发于青少年,主要表现为局部肿块,采取积极的综合治疗方案是主要治疗方法,预后与有无远处转移及治疗模式相关。Background and Objective：Extraskeletal Ewing＇s sarcoma （EES） is a rare,rapidly growing,round-cell,malignant tumor that can develop in the soft tissues at any location. This study was to analyze the clinical features,diagnosis and treatment of EES. Methods：Clinical data of 18 patients with EES,treated at Sun Yat-sun University Cancer Center between 1995 and 2007,were analyzed. Reults：Of the 18 patients,13 were male and 8 were female,aged from 8 months to 60 years. Twelve （66.7%） patients were between 5-25 years of age. Eight （44.4%） patients had tumors originated from low extremities.Sixteen patients had masses at their first visit. Sixteen patients were treated by the combined modality therapy,and 2 patients were treated by the single modality therapy. The 1-,3-and 5-year actuarial survival rates were 82.4%,64.2% and 32.1%,respectively. The presence of metastatic disease at the time of diagnosis and the mode of treatment were prognostic factors. Conclusions：EES is common in adolescent. It often manifests as a localized mass. The combined modality therapy is recommended for this disease. The presence of metastatic disease at the time of diagnosis and the mode of treatment are prognostic factors.

关 键 词：骨外EWING肉瘤 临床特征 诊断 治疗 

分 类 号：R730.4[医药卫生—肿瘤]