伴有凶杀行为精神分裂症患者听觉感觉门控P50的随访研究  

Follow-up study on auditory sensory gating P50 in schizophrenia patients with homicide

作　　者：王红星[1] 马辛[1] 甄文凤[1] 王玉平[2] 毛薇[2] 

机构地区：[1]首都医科大学附属北京安定医院,北京100088 [2]首都医科大学宣武医院

出　　处：《中国神经精神疾病杂志》2010年第3期153-156,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：首都医学发展科研基金(编号:2005-536);北京市科技新星计划(编号:2006A35);北京市科技计划项目(编号:Z09050600630903);北京市卫生系统高层次卫生技术人才培养计划(编号:2009-3-53)

摘　　要：目的随访分析伴有凶杀行为的精神分裂症患者听觉感觉门控电位P50的变化。方法采用条件-测试刺激模式,对25例伴有凶杀行为的精神分裂症患者(患者组)和27名正常对照者(对照组)进行P50检测和比较,经过抗精神病药物治疗3个月后,有11例患者完成了P50随访,同时应用阳性和阴性症状量表(PANSS)评定患者的精神症状。结果①与对照组相比,患者组在入组未用药时和随访3个月时的S2-P50波幅均较高(P<0.01),S2/S1比值均较大(P<0.01),S1-S2差值(P<0.05)和100(1-S2/S1)值均较小(P<0.01)。患者组P50波幅、潜伏期和P50抑制指标在入组时和3个月时的差异均无统计学意义(P>0.05)。②与入组时相比,3个月时患者组PANSS总分、阳性量表分、一般精神病理量表分以及反应缺乏、思维障碍、激活性、偏执、抑郁、攻击等6个症状群得分降低(P<0.05)。③患者组在入组时和3个月时S2/S1比值、S1-S2差值和100(1-S2/S1)等P50抑制指标与病程、PANSS各指标均无相关(P>0.05)。结论伴有凶杀行为的精神分裂症患者感觉门控存在异常,且P50抑制指标可能是该人群的素质指标。Objective To investigate the auditory sensory gating P50 in schizophrenia patients with homicide during three months of follow up.Methods Twenty-five patients with schizophrenia patients with homicide and 27 healthy adults matched with age and education level were recruited in the present study.P50 was recorded in twenty-seven normal controls and twenty-five schizophrenia patients at the baseline.P50 was repeatedly recorded in eleven patients who completed the follow-up at three months following antipsychotics treatment.The psychotic symptoms of patients were assessed with Positive and Negative Syndrome Scale（PANSS）at the same time.Results ①In comparison with normal controls,schizophrenia patients with homicide showed increased S2-P50 amplitude（P0.01）,increased S2/S1 ratio（P0.01）,decreased S1-S2（P0.05）,and 100（1-S2/S1）（P0.01）at the baseline and after three months treatment.The differences in P50 amplitude,latency,and P50 suppression index between the baseline and after three-month treatment in schizophrenia patients with homicide were not significant（P0.05）.② Schizophrenia patients with homicide after three-month treatment showed decreased PANSS total scale,positive scale,general psychopathology scale,and six symptoms scales such as lack of response,thought disorder,activation,paranoid,depression,and aggression（P0.05）.③ No significant correlations were found between the S2/S1 ratio,S2-S1,and 100（1-S2/S1）with disease duration,PANSS scores,and six symptoms scales at either baseline or after three-month treatment（P0.05）.Conclusions Schizophrenia with homicide has sensory gating deficits and P50 suppression index might be a stable trait maker for schizophrenia with homicide.

关 键 词：精神分裂症 凶杀行为 感觉门控 P50 

分 类 号：R749.3[医药卫生—神经病学与精神病学]