微电极引导立体定向核团毁损和脑深部电刺激治疗帕金森病  

The efficacy of microelectrode-guided stereotactic ablative surgery and deep brain stimulation on patients with Parkinson's disease

作　　者：李建国[1] 陈宝友[1] 武慧丽[1] 商崇智[1] 梁晋[1] 赵永青[1] 董月青[1] 

机构地区：[1]武警医学院附属医院脑系科中心,天津300162

出　　处：《立体定向和功能性神经外科杂志》2010年第1期1-3,共3页Chinese Journal of Stereotactic and Functional Neurosurgery

摘　　要：目的研究微电极引导立体定向颅内核团毁损和脑深部电刺激手术(deep brain stimulation,DBS)治疗帕金森病的临床疗效。方法分析我院116例应用微电极引导立体定向核团毁损术和85例应用脑深部电刺激术治疗的帕金森病患者的临床资料,获得术前、术后和DBS开启后6个月、1年、3年及5年的不同服药状态下帕金森病联合评分量表(UPDRS)的评分,比较手术前后UPDRS运动评分的差异。结果核团毁损术和DBS在术后6个月、1年和3年的随访中均能显著改善患者术前UPDRS运动评分,在第5年仅DBS组UPDRS运动评分较术前有改善,同时DBS组患者术后抗帕金森病药物用量较术前减少。结论核团毁损和脑深部电刺激手术均能显著改善帕金森病患者的UPDRS运动评分,DBS疗效更为长久。Objective To study the efficacy of microelectrode-guided stereotactic ablative operation and deep brain stimulation on patients with Parkinson＇s disease.Methods 116 patients underwent ablative operation and 85 patients underwent deep brain stimulation.The efficacy was assessed by the Unified Parkinson＇s Disease Rating Scale（UPDRS） pre-and post-operation with on and off medication.Results Both ablative operation and deep brain stimulation reduced UPDRS scores significantly at 6 months,1 year and 3 years after surgery.Only DBS group demonstrated significant improvement in UPDRS scores at 5 years after operation.And the dosage of antiparkinsonian medication was significantly reduced after the surgical procedure in DBS groups.Conclusion Both ablative operation and deep brain stimulation significantly improved UPDRS scores in patients with Parkinson＇s disease.DBS showed better long-term effect.

关 键 词：帕金森病 核团毁损术 脑深部电刺激术 

分 类 号：R742.5[医药卫生—神经病学与精神病学]