窖蛋白-1、基质金属蛋白酶-2与乳腺肿瘤的侵袭和转移  

Caveolin-1,MMP-2 in the Invasion and Metastasis of Breast Cancer

作　　者：王洋[1] 封爽[1] 邹伟[1,2] 

机构地区：[1]辽宁师范大学生命科学学院,大连116029 [2]辽宁省生物技术与分子药物研发重点实验室,大连116029

出　　处：《中国生物化学与分子生物学报》2010年第4期311-314,共4页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.30570225)~~

摘　　要：窖蛋白(caveolin)是分子量为21～24 kD的整合膜蛋白,是胞膜窖(caveolae)的标志性结构分子,其家族成员窖蛋白-1(caveolin-1,Cav-1)参与细胞内许多重要的生命活动.近来研究发现,窖蛋白-1与乳腺上皮细胞转化及乳腺癌的发生密切相关.基质金属蛋白酶(matrix metalloproteinases,MMPs)是基质降解代谢的主要酶类,几乎能降解细胞外基质和基底膜的所有成分,其家族成员明胶酶A(MMP-2)在乳腺癌的浸润和转移过程中起重要作用.新近发现,窖蛋白-1与基质金属蛋白酶-2在胞膜窖中共定位,窖蛋白-1通过抑制基质金属蛋白酶-2的激活来抑制乳腺癌的侵袭和转移,起到肿瘤抑制因子的作用.本文对窖蛋白-1与基质金属蛋白酶-2各自在乳腺肿瘤侵袭转移中的作用及两者关系的研究进行综述.Caveolin is a 21 ～ 24 kD essential membrane protein of the caveolae.Caveolin-1,one of caveolin family members,participates in many important activities of the cells.Recent studies found that caveolin-1 closely related to the transformation and carcinogenesis of mammary epithelial cells.Matrix metalloproteinases（MMPs） are key enzymes to degrade the components of the extracellular matrix and basement membrane,including MMP-2 that is involved in invasion and metastasis of the breast cancers.Caveolin-1 was recently recognized as a tumor suppressor,to inhibit the invasion and metastasis of breast cancer by supressing the activation of MMP-2 and co-localized with MMP-2 in the caveolae.This review focuses on the functional relationship of caveolin-1 and MMP-2 in breast cancer invasion and metastasis.

关 键 词：乳腺癌 窖蛋白-1 基质金属蛋白酶-2 肿瘤转移 

分 类 号：Q789[生物学—分子生物学] R73-3[医药卫生—肿瘤]