放射性碘治疗对甲状腺癌术后患者腮腺损害的观察  

Observation of parotid dysfunction in patients with thyroid carcinoma treated by radioiodine therapy

作　　者：邬宏恂[1] 叶万忠[2] 臧亚萍[1] 王隽[1] 朱蓓琳[1] 

机构地区：[1]江苏省原子医学研究所(卫生部核医学重点实验室)附属江原医院超声科,江苏省无锡市214063 [2]江苏省原子医学研究所(卫生部核医学重点实验室)附属江原医院核医学科,江苏省无锡市214063

出　　处：《临床超声医学杂志》2010年第3期178-180,共3页Journal of Clinical Ultrasound in Medicine

摘　　要：目的观察甲状腺癌术后放射性碘治疗对腮腺功能的损害,并分析其影响因素。方法对26例甲状腺癌术后接受碘治疗的患者进行腮腺功能核素检查及超声检查。结果治疗后3 d腮腺浅叶厚径较治疗前增厚(P<0.05),以后呈减小趋势;超声评分的高点出现在治疗后3个月,12个月后评分仍维持在高位。患者右侧腮腺摄取指数在治疗前后差异无统计学意义(P>0.05),放射性碘治疗后腮腺分泌率下降,差异有统计学意义(P<0.05)。多元回归分析显示基础腮腺功能和放射剂量是影响碘治疗后腮腺功能的独立风险因素。结论超声能观察放射性碘对腮腺的损害,放射性碘治疗后腮腺的功能受治疗前基础腮腺功能和放射剂量影响,而与其他因素无关。Objective To observe the parotid dysfunction in patients with thyroid carcinoma treated by radioiodine therapy, and to analyze the influencing factors. Methods Twenty - six patients with thyroid carcinoma treated by radioiodine therapy were enrolled. The parotid was examined by nuclide method and ultrasound. Results The superficial lobes of the parotid was enlarged 3 days after the treatment, and it tended to decrease. Ultrasonography score reached to the peak 3 months after radioiodine therapy. The score still maintained at the peak 12 months later. There was no significant difference of uptake index in right parotid before and after the therapy （P 〉 0.05 ）. The parotid secretion rate was decreased, there was significant difference before and after therapy（P 〈 0.05 ）. Logic regression analysis showed parotid basic function and radiation dose were independent risk factors. Conclusion Ultrasound can observe the dysfunction of parotid after radiotherapy, and the parotid function is correlated with basic function and radiation dose.

关 键 词：放射性碘治疗 腮腺损害 超声检查 

分 类 号：R730.41[医药卫生—肿瘤]