受体靶向干预与肝星状细胞活化功能的调控研究  

Research on receptor-targeted intervention and regulation of hepatic stellate cell activation

作　　者：朱长红[1] 吴建新[1] 周韵斓[1] 唐东[1] 陈源文[1] 范建高[1] 

机构地区：[1]上海交通大学医学院附属新华医院消化内科,上海200092

出　　处：《胃肠病学和肝病学杂志》2010年第4期302-305,共4页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家自然科学基金项目(30672675)

摘　　要：异常的生物信息分子调控并维持肝星状细胞(HSC)活化及其高功能、永生性等生物学行为。它们的分子信息转导依赖于细胞膜不同的受体-配体间的特异性结合。针对HSC细胞膜表面6-磷酸甘露糖/胰岛素生长因子Ⅱ型受体(M6P/IGF-ⅡR)、精氨酸-甘氨酸-天门冬氨酸(RGD)受体及TGF-βⅡ型受体,人们设计了人工配体或修饰配体、以载体形式连接药物等特异性靶向干预的生物大分子,试图调控或阻断这些分子信息通路的转导,实现抑制HSC的活化与功能表达。The changed behaviors of hepatic stellate cell（HSC） such as activation,hyperfunction and immortality are triggered and maintained by lots of abnormal biologic molecules.These biologic factors initiate their intracellular signal transduction via specific receptors on the cell membranes.Specific receptor-targeted macromolecules were developed artificially as modified ligands or ligands used as drug carriers for binding to mannose 6-phosphate/insulin-like growth factor-Ⅱ receptor（M6P/IGF-ⅡR）,RGD receptor,and TGF-βⅡreceptor,trying to control,modulate or block the interaction among these molecules in order to normalize the function of HSC.

关 键 词：受体 靶向干预 肝星状细胞 调控 

分 类 号：R57[医药卫生—消化系统]