环氧化酶2基因-1195G/A基因型和病毒性乙型肝炎相关性肝癌发病风险相关的病例对照研究  

The relationship between Cyclooxygenase-2 gene-1195G/A genotype and risk of HBV-induced HCC:a case-control study in Han Chinese people

作　　者：刘丽凤[1] 张金良[2] 林菊生[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝病研究所,湖北武汉430030 [2]滨州医学院附属医院

出　　处：《胃肠病学和肝病学杂志》2010年第4期333-335,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：国家重点基础研究发展计划(课题号2007CB512903);国家自然科学基金(课题号30872237)

摘　　要：目的探讨环氧化酶2(COX-2)基因启动子区的单核苷酸多态性,并研究其与病毒性乙型肝炎相关性肝癌发病风险的关系。方法采取以人口为基础的病例对照研究,收集湖北省汉族人630例:210例病毒性乙型肝炎相关性肝癌患者、210例慢性病毒性乙型肝炎患者和210例健康对照。通过聚合酶链反应-限制性片段多态性的方法,研究其启动子区-1195位单核甘酸多态性:-1195 G/A。结果-1195 A等位基因携带者乙肝相关性肝癌的发病风险增高(OR=1.388,95%CI-1.057-1.823)。结论-1195 A等位基因可能会成为乙肝相关性肝癌高危人群的预测标记。Objective To identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and to evaluate their effects on the risk of primary hepatocellular carcinoma（HCC） with hepatitis B virus（HBV） infection.Methods A population-based,case-control study enrolling 630 Han Chinese people in Hubei province was collected.Subjects included primary HCC patients with HBV infection（n=210）,chronic hepatitis B cases（n=210） and healthy Chinese Han people（n=210）.-1195G/A polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）.Results-1195A allele carriers had a higher risk of HCC with HBV infection（OR=1.388,95% CI=1.057-1.823）.Conclusion The-1195A allele may be used as a marker in screening individuals at the high risk of HCC with HBV infection.

关 键 词：环氧化酶2 单核甘酸多态性 易感性 病毒性乙型肝炎相关性肝癌 

分 类 号：R735.7[医药卫生—肿瘤]