^(11)C-CFT脑PET显像在早期帕金森病诊断中的临床应用  

Application of ^(11)C-CFT PET in the diagnosis of Parkinson’s disease with early-stage

作　　者：王慧春[1] 左传涛[1] 黄喆慜[1] 王长梅[1] 华逢春[1] 赵军[1] 管一晖[1] 

机构地区：[1]复旦大学附属华山医院PET中心,上海200235

出　　处：《中国临床医学影像杂志》2010年第4期229-232,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:探讨11C-甲基-N-2β-甲基酯-3β-(4-F-苯基)托烷(11C-CFT)脑多巴胺转运蛋白(Dopamine transporter,DAT)PET显像在早期帕金森病(Parkinson's disease,PD)诊断中的临床应用价值。方法:98例临床诊断为原发性早期PD患者(Hoehn&Yahr1~2级)和20例正常对照者进行11C-CFT脑PET显像,应用感兴趣区(ROI)法分别划取左右尾状核、前壳核和后壳核ROI,以基底节各亚区与小脑的放射性比值作为半定量指标,比较早期PD组与正常对照组基底节DAT分布的差异。结果:早期PD组双侧前壳核、后壳核11C-CFT摄取明显减少,分别降至对照组的40.7%和23.5%(P<0.05),以起病对侧减少为主,后壳核区域最为显著;双侧尾状核CFT摄取降至对照组的97.4%(P>0.05)。早期偏侧PD患者起病同侧("健"侧)前壳核、后壳核CFT摄取分别降至对照组的48.5%和30.5%(P<0.05),同侧尾状核降至98.0%(P>0.05)。结论:11C-CFT脑DAT PET显像有助于PD的早期诊断。Objective： To evaluate the clinical application values of ^11C-methyl-N-2β-carbomethoxy-3β-（4-fluorophenyl） tropane（^11C-CFT） PET imaging for dopamine transporter（DAT） in diagnosing Parkinson＇s disease （PD） at its early stage. Methods： Ninty-eight patients with early-stage idiopathic PD （Hoehn ＆ Yahr 1-2）, and 20 age-matched healthy volunteers were recruited. Using region of interest （ROI） technique to measure the CFT uptake ratio of bilateral striatum of all the above subjects including the subregions of candate nucleus, anterior putamen and posterior putamen, which were applied to compare the difference of DAT distribution between the early stage PD and control group. Results： In the early PD group, ^11C-CFT uptake in bilateral anterior and posterior putamen was significantly reduced to 40.7% and 23.5% of the control group respectively （P〈 0.05）, where the major reduction occurred in the putamen opposite to the predominant symptoms, and the most .apparent reductive region was posterior putamen. The CFT uptake of bilateral caudate nucleus was reduced to 97.4% of the control group （P〉0.05）. In the group of hemi-parkinsonian patients（Hoehn ＆ Yahr 1-1.5）, the CFT uptake in the ipsilateral（preclinieal） anterior and posterior putamen was significantly reduced to 48.5% and 30.5% of the age-matched controls respectively （P〈0.05）, while the ipsilateral caudate nucleus was reduced to 98.0%（P〉0.05）. Conclusions： ^11C-CFT DAT PET imaging is helpful in early diagnosis of Pakinson＇s disease.

关 键 词：帕金森病 正电子发射断层显像术 

分 类 号：R742.51[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]