顺铂-白蛋白微球舌动脉导向治疗舌癌的临床病理研究  被引量:3

Clinical Pathology Study of Lingual Carcinoma Treatment with CDDPAMS Microcapsules Through Lingual Artery

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作  者:王昌美[1] 李宏卫[1] 温玉明[1] 傅风华[1] 李龙江[1] 王晓毅[1] 

机构地区:[1]华西医科大学口腔医学院

出  处:《华西口腔医学杂志》1998年第2期134-137,I006,共5页West China Journal of Stomatology

基  金:国家教委博士点基金

摘  要:采用自行研制的平均粒径56.3μm的顺铂-白蛋白微球(CDDP-AMS)100mg(含CDDP13.6mg),经舌动脉灌注治疗舌部鳞癌患者11例,临床及病理观察,灌注后4周的病理标本已无癌巢及确切散在癌细胞,灌注后5~6周临床肿瘤创面已消失,但因患侧舌体有纤维组织形成,难于判定肿瘤瘤体变化,通过4例在灌注后未行瘤体切除病例半年以上观察,肿块消失,舌体柔软。11 patients with lingual carcinorma were treated by artery chemoembolization with 100mg CDDPAMS microcapsules (CDDP 13.6 mg) through lingual artery,and the average diameter of microcapules was 56.3 μm. There was no obvious carcinoma cell or carcinoma tissue in pathologic specimens of the tissue after 4 weeks of treatment. After 5 ̄6 weeks of chemoembolization, the clinical tumor ulcer disappeared, but it was difficult to judge the change of the tumor because of local fiber tissue. After 6 months, by observation of 4 patients whose tumors had not been excised, it was found that the infiltuation mass of primary carcinoma disappeared and tongue body became soft. It suggests that artery chemoembolization with CDDPAMS microcapsules is an effcient way of lingual carcinoma treatment.

关 键 词:顺铂 白蛋白微球 鳞状细胞癌 舌肿瘤 栓塞疗法 

分 类 号:R739.860.5[医药卫生—肿瘤]

 

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