鼻咽鳞癌肿瘤分化与c-fos癌基因表达的关系  

The correlation between the cfos expression and the tumor differentiation of nasopharyngeal carcinoma (NPC)

作　　者：陈茂怀[1,2] 李川军[1,2] 杜家辉 罗锡源[1,2] 

机构地区：[1]汕头大学医学院病理教研室 [2]香港中文大学医学院病理解剖及细胞学系

出　　处：《临床与实验病理学杂志》1998年第2期128-130,I021,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的：探讨鼻咽鳞癌组织分化与ｃ－ｆｏｓ癌基因的关系。方法：采用免疫组化ＡＢＣ法和图象分析技术检测１２５例鼻咽癌的ｃ－ｆｏｓ癌基因表达产物及其阳性胞核面积。结果：非角化性鳞癌ｃ－ｆｏｓ癌基因阳性率（４４．４％）高于角化性鳞癌（１７．７％），前者中低分化鳞癌与未分化癌之间的ｃ－ｆｏｓ阳性率差异没有显著性，而核面积明显增大的未分化泡状癌细胞核未见阳性表达。结论：鼻咽鳞癌细胞的分化程度与ｃ－ｆｏｓ癌基因的表达密切相关。Purpose To evaluate the correlation between the cfos expression and the tumor differentiation of nasopharyngeal carcinoma. Methods The expression of the cfos protein was examined in 125 cases of NPC using immunohistochemistry and the nuclear area of positive immunostain was also measured with image analyzer. Results Positivity rate of cfos protein was higher in nonkeratinizing squamous cell carcinoma (NKSCC) (444%) than in keratinizing one (176%) (P<005). No significant difference was found in positivity rates between the differentiated and the undifferentiated carcinoma of NKSCC (P>005). Conclusions The cfos expression is related closely to the cellular differentiation of the cancer cells in NPC.

关 键 词：鼻咽肿瘤 鳞癌 分化 C-FOS基因 基因表达 

分 类 号：R739.630.2[医药卫生—肿瘤]