缺血性脑血管病急性期血浆溶血磷脂酸水平的变化  

A clinical study for the dynamic change of LPA level in plasma of patients with acute ischemic cerebrovascular disease

作　　者：娄卫东 谢紫明 孙伟[2] 

机构地区：[1]龙泉市人民医院神经内科,浙江省龙泉323700 [2]黑龙江省哈尔滨医科大学第一临床医学院神经内科

出　　处：《中国基层医药》2010年第7期865-866,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的观察缺血性脑血管病患者急性期血浆溶血磷脂酸（LPA）水平的动态变化，探讨LPA在缺血性脑血管病急性期的意义。方法随机选择缺血性脑血管病住院患者103例，分为短暂性脑缺血发作（TIA）组、脑血栓形成组和腔隙性脑梗死组，测定发病后第1、2、3、7天及健康对照组血浆LPA含量。结果TIA组、脑血栓形成组和腔隙性脑梗死组患者血浆LPA水平均显著高于健康对照组（P〈0．01），于发病后24h内开始升高，呈时间动态变化过程。结论LPA与缺血性脑血管病的发生发展密切相关，对指导临床治疗及预防有重要意义。Objective To observe the dynamic change of lysophosphatidic acid（LPA） level in plasma of patients with acute ischemic cerebrovascular disease, and to find the significance of LPA. Methods We examined LPA level in fresh plasma of 103 patients with transient ischemia attack,cerebral thrombosis or lacuna infarct at I st day, 2nd day,3rd day and 7th day after onset of the disease. We also examined the plasma of 30 healthy controls. Results An elevated LPA level was seen in cases with ischemic cerebrovascular disease compared with heahhy controls. Meanwhile,LPA level was related with the time after onset of the disease. Conclusion LPA plays an important role in the process of acute ischemic cerebrovascular disease, and LPA level may be significant for clinical therapy and prognosis of acute ischemic cerebrovascular disease.

关 键 词：脑缺血 溶血磷脂酸 

分 类 号：R74[医药卫生—神经病学与精神病学]