Reference point of floating-reference method for blood glucose sensing  

作　　者：杨越 陈文亮 史振志 徐可欣 

机构地区：[1]State Key Laboratory of Precision Measuring Technology and Instrument Tianjin University

出　　处：《Chinese Optics Letters》2010年第4期421-424,共4页中国光学快报（英文版）

基　　金：supported by the"111"Project of China (No.B07014);the National Natural Science Foundation of China(Nos.30600126,30700168,and 60938002);and the Research Fund for the Doctoral Program of Higher Education of China(No.20070056069)

摘　　要：A problem in terms of the accuracy of noninvasive measurement of blood glucose with near-infrared（NIR） spectroscopy is mainly caused by the weak glucose signal and strong background variations.We report the existence of the radial reference point in a floating-reference method,which is supposed to solve this problem.Based on the analysis of the infinite diffusion theory,the local condition of the reference point is deduced theoretically.Then the experiments using the intralipid solutions are constructed to testify the existence of the reference point.In order to further validate our results,Monte Carlo simulations are performed to calculate the diffused light distribution according to the variation of the glucose concentration in the intralipid solutions.All the reference points existing in three-layer skin model are also listed at the wavelength of 1200-1700 nm.A problem in terms of the accuracy of noninvasive measurement of blood glucose with near-infrared（NIR） spectroscopy is mainly caused by the weak glucose signal and strong background variations.We report the existence of the radial reference point in a floating-reference method,which is supposed to solve this problem.Based on the analysis of the infinite diffusion theory,the local condition of the reference point is deduced theoretically.Then the experiments using the intralipid solutions are constructed to testify the existence of the reference point.In order to further validate our results,Monte Carlo simulations are performed to calculate the diffused light distribution according to the variation of the glucose concentration in the intralipid solutions.All the reference points existing in three-layer skin model are also listed at the wavelength of 1200-1700 nm.

关 键 词：BLOOD Computer simulation Infrared devices Infrared spectroscopy Monte Carlo methods 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]