CD44 v6在口腔鳞状细胞癌中表达的意义  

The Role of CD44 v6 Expression in Oral Sqaumous Cell Carcinoma

作　　者：朱虹[1] 曾庆华 白淑清 王影[1] 欧阳喈[1] 

机构地区：[1]白求恩医科大学口腔医学院

出　　处：《华西口腔医学杂志》1998年第3期198-200,I009,共4页West China Journal of Stomatology

摘　　要：应用ＣＤ４４ｖ６单克隆抗体对３０例口腔鳞状细胞癌进行了免疫组织化学研究。实验发现：ＣＤ４４ｖ６在正常口腔粘膜上皮中的基底细胞层及近基底１／３的上皮细胞膜上呈阳性表达，上皮表层细胞几乎呈阴性表达。在３０例鳞状细胞癌的免疫组织化学染色中大部分鳞状细胞癌的癌细胞染色阳性，但染色强度随肿瘤的分化程度不同而不同，分化高的癌巢上皮细胞膜染色均匀而浓重，分化差的癌巢上皮细胞膜染色弱而呈细线状，转移灶内癌巢上皮ＣＤ４４ｖ６染色较弱。实验表明：ＣＤ４４ｖ６的表达在判断癌的分化、浸润。cases of oral squamous cell carcinoma were selected and studied with immunohistochemical monoclone antibody CD44 v6. The results were that CD44 v6 showed positive expression in basal cell layer and near 1/3 base layer of epithelia of normal oral mucous epithelia. Majority of 30 cases of squamous cell carcinoma were positive stained by immunohistochemical stain, but the stain degree was different relating to different differentiation degree of tumor. A heavy and even membrane stain was found in the high differential epithalial cell of carcinoma nest, and an uneven and thin linear stain pattern was present in the epithelia cell membrane of the low differentiated carcinoma nest, while the carcinoma epithelia in the metastatic nest was lightly stained with CD44 v6. The experiment indicates that expression of CD44 v6 is significant in carcinoma differentiation, invasion and metastasis.

关 键 词：鳞状细胞癌 CD44V6 免疫组织化学 口腔肿瘤 

分 类 号：R739.802[医药卫生—肿瘤]