胃癌组织中c-FLIP及Ki-67表达的研究  

Expression of c-FLIP and Ki-67 in gastric carcinoma

作　　者：吕洪光[1] 高梅鷟[1] 魏争[1] 宋治[1] 杨勇[1] 郑智星[1] 

机构地区：[1]哈尔滨医科大学附属第一医院脾胃及门静脉高压症外科,150001

出　　处：《国际遗传学杂志》2010年第2期122-124,共3页International Journal of Genetics

基　　金：黑龙江省教育厅基金资助（11531199）

摘　　要：目的研究胃癌组织中c—FLIP及Ki-67的表达情况，并依此探讨胃癌细胞的凋亡与增殖之间的关系。方法应用免疫组织化学的方法研究c—FLIP及Ki-67在100例胃癌标本中及100例胃良性疾病标本中的表达情况。结果在胃癌组织中c—FLIP（Х^2=35．17，P〈0．01）及KI有较高表达（u=13．52，P〈0．01）；不同分化程度的胃癌标本中，c—FLIP表达差别有统计学意义（Х^2=14．83，P〈0．01），而KI差别无统计学意义（u=1．00，P〉0．05）。结论在胃癌的发生与发展中，细胞凋亡受抑制与细胞增殖过度之间存在相互协同作用。Objective To analyze the expression of c-FLIP and Ki-67 in gastric carcinoma. Methods Immunohistoehemical methods were used to analyze the expressions of e-FLIP and Ki-67 from 100 postoperative specimens with gastric carcinoma and 100 specimens with begnin gastric diseases. Results Gastric carcinomas have high expression of c-FLIP （Х^2 =35. 17,P 〈0.01 ）and KI（ u = 13.52,P 〈0.01 ） ; differentiation grade of gastric carcinomas are associated with increased expression of c-FLIP（Х^2 = 14. 83, P 〈 0. 01 ） , and similarly, with expression of KI（ u = 1.00, P 〉 0.05 ）. Conclusion The c-FLIP, as one of new anti-apoptosis proteins, expresses itself in gastric carcinoma, and thus interferes with apoptosis. The progression of gastric carcinoma results from the imbalance between cell proliferation and cell death.

关 键 词：胃癌 凋亡 细胞增殖 

分 类 号：R735.2[医药卫生—肿瘤]