大肠癌肿瘤细胞组织因子的表达及其临床意义  

Expression and clinical significance of tissue factor in human colorectal cancer cells

作　　者：沈洁[1] 王晓华[2] 王红霞[3] 

机构地区：[1]南方医科大学附属小榄医院,内镜室,广东中山528415 [2]南方医科大学附属小榄医院,普通外科,广东中山528415 [3]南方医科大学附属小榄医院,病理科,广东中山528415

出　　处：《岭南现代临床外科》2010年第2期89-91,共3页Lingnan Modern Clinics in Surgery

摘　　要：目的探讨组织因子在大肠癌肿瘤细胞的过度表达及其临床意义。方法免疫组化染色检测32例大肠癌手术切除标本中组织因子蛋白的表达,分析组织因子蛋白过度表达与大肠癌的临床分期、淋巴结转移以及肝转移等的关系。结果大肠癌肿瘤细胞中,组织因子蛋白的过度表达率为62.5%(20/32例);Duke分期高的大肠癌病例,肿瘤细胞的组织因子蛋白过度表达率较高;肿瘤细胞的组织因子蛋白过度表达的病例倾向于发生大肠癌淋巴结转移和肝转移。结论组织因子在大肠癌肿瘤细胞中存在过度表达,并在大肠癌的发生发展中可能发挥重要作用。Objective To investigate the overexpression and clinical significance of tissue factor （TF） in human colorectal cancer cells. Methods In the surgical resected specimen of 32 cases with colorectal cancer, the expressions of TF protein were detected by immunohistochemical staining. The relationship between the overexpression of TF protein and clinical staging, lymph node and liver metastasis were analyzed. Results In the colorectal cancer cells, the overexpression rate of TF protein was 62.5% （20/32）. In the cases of the high Duke＇s stage of tumor cells were higher. It had tendency to occur lymph node and liver metastasis. Conclusion In the tumor cells of colorectal cancer, TF is existence in overexpression state. It is very important to occurrence and development of colorectal cancer.

关 键 词：大肠癌:组织因子 免疫组织化学 

分 类 号：R735.3[医药卫生—肿瘤]