RASSF1A启动子甲基化与非小细胞肺癌TNM分期关系的Meta分析  

Meta-analysis:The significance of the methylation of RASSF1A promoter in the early diagnosis of non-small cell lung cancer

作　　者：刘利东[1] 黄金水[2] 谭兆珍[3] 刘玉仪[1] 

机构地区：[1]广州医学院第一附属医院检验科,广州510120 [2]中山大学附属第二医院输血科,广州510120 [3]中山大学附属第二医院内科,广州510120

出　　处：《岭南现代临床外科》2010年第2期142-144,共3页Lingnan Modern Clinics in Surgery

基　　金：广州市医药卫生科技项目(2008-YB-155)资助

摘　　要：目的探讨RASSF1A启动子甲基化与非小细胞肺癌TNM分期的关系。方法在中外数据库中收集研究非小细胞肺癌组织RASSF1A启动子甲基化的文献,制定严格的入选和剔除标准,最后入选的文献用META分析软件Review Manager 5.0对甲基化与TNM分期进行分析,计算合并的OR值。结果共有5篇文献入选,NSCLC中Ⅰ期与Ⅱ-Ⅳ期差异分析显示在95%CI时,合并OR值为1.24(范围在0.90-1.72),Z=1.30,P=0.47>0.05,表明RASSF1A启动子甲基化在各期肺癌均可出现,在早期和中晚期肺癌组织中RASSF1A甲基化程度不存在差别(P>0.05)。结论 RASSF1A启动子甲基化是非小细胞肺癌发生发展过程中的一个分子事件,与非小细胞肺癌TNM分期无明显相关性,可以作为非小细胞肺癌的早期分子诊断候选指标。Objective To study the relationship between the methylation of RASSF1A promoter and the TNM stage of non-small cell lung cancer（NSCLC）. Methods The literature on the methylation of RASSF1A promoter in the tissue of NSCLC were collected and the recepted and rejected criteria were established strictly. These articles were evaluated by Review Manager 5.0 and the combined OR between methylation of RASSF1A and TNM stages was got. Results A total of 5 articles were accepted, the different analysis between I stage and II- IV stages of NSCLC showed that the combined OR was 1.24（0.90-1.72）, and Z=l.30, P=0.47 when CI was 95%. It indicated that the methylation of RASSF1A promoter occured in different stage and the rate of methylation had not significance difference between early and mid-late NSCLC tissues （P〉0.05）. Conclusions The methylation of RASSF1A promoter was a molecular event during the development of NSCLC and there was not distinct correlation between methylation of RASSF1A promoter and the TNM stages of NSCLC and the methylation can be a candidature of early molecular diagnosis of NSCLC.

关 键 词：非小细胞肺癌 RASSF1A 启动子 甲基化 

分 类 号：R734.2[医药卫生—肿瘤]