负化学源气质联用快速测定母乳中的十溴联苯醚  

Rapid determination of deca-brominated diphenyl ether(BDE209) in human milk by GC-NCI-MS

作　　者：张玉黔[1] 代澎[1] 胡海涛[1] 

机构地区：[1]沈阳市疾病预防控制中心,沈阳110031

出　　处：《中国卫生检验杂志》2010年第4期750-751,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的：本实验通过单独分离母乳中的十溴联苯醚（BDE209）,建立稳定性同位素内标稀释负化学源气质联用（NCI-MS）快速测定十溴联苯醚（BDE209）的方法。方法：母乳样品冷冻干燥,经正己烷-二氯甲烷索氏提取过多层硅胶柱,净化分离,进样检测。结果：实验结果表明,相关系数r≥0.9999,仪器检出限为4.4 pg,方法检出限为0.08 ng。在0.5~5000μg/L浓度范围内,其平均回收率为61.2%~116%,相对标准偏差范围为4.9%~8.6%。结论：本方法快速、准确,具有较低的检出限,较好的回收率和精密度,符合分析测定的要求,可用于母乳样品的检测。Objective：To establish a rapid gas chromatography - negative chemical ionization - mass spectric method （ GC - NCI- MS ） for the quantitative determination of deca - brominated diphenyl ether （BDE209） by separated target in human milk. Me,otis：The frozen dry human milk samples were purified by mixture silica columns with hexane and dichloromethane and determined by GC - NCI - MS. Results： The correlation coefficients were above 0. 9999, the instrumental detection limits were 4.4 pg and the method detection limits （MDLs） were 0.08 ng. Between 0.01 and 1.0 μg/L concentration, the average recovery ranged between 61.2% and 116%. The relative standard deviations ranged between 4.9 and 8. 6% for BDE209 measured in human milk samples. Conclusion：It is a rapid, accurate, precise, low -limit and high -recovery method for the trace analysis of the BDE209 in human milk.

关 键 词：十溴联苯醚 负化学源 气质联用 母乳 

分 类 号：O657.63[理学—分析化学]