含铬、蜂胶奶粉对实验性糖尿病小鼠的降血糖作用  

Glucose-lowering effects of milk powder containing chromium and propolis on experimental diabetic mice

作　　者：王亚东[1] 王海玉[1] 李立[1] 张聪恪[1] 张桂霞[1] 张焱[1] 刘翠娥[1] 

机构地区：[1]河南省疾病预防控制中心检测检验中心毒理室,郑州450016

出　　处：《中国卫生检验杂志》2010年第4期775-776,共2页Chinese Journal of Health Laboratory Technology

摘　　要：目的:研究含铬、蜂胶奶粉对实验性糖尿病小鼠血糖的影响。方法:用四氧嘧啶建立糖尿病小鼠模型,依据血糖水平随机分为4组:低剂量组(0.5 g/kg)、中剂量组(1.0 g/kg)、高剂量组(3.0 g/kg)和模型对照组。另设正常对照组和高剂量组。连续灌胃30 d,测定血糖值。结果:3.0 g/kg剂量组空腹血糖、2 h血糖和血糖曲线下面积与模型对照组比较差异有统计学意义(P<0.05);含铬、蜂胶奶粉对正常小鼠空腹血糖无明显影响。结论:在本实验条件下,含铬、蜂胶奶粉对实验性糖尿病小鼠的血糖有降低作用。Objective：To study the effects of milk powder containing chromium and propolis on blood glucose in experimental diabetic mice.Methods：The models of experimental diabetic mice were established by injecting allocon through caudal vein,and animals were randomly divided into four groups： low dose group（0.5 g/kg）,middle dose group（1.0 g/kg）,high dose group（3.0 g/kg） and diabetic group,according to the level of blood glucose.Meanwhile,normal animals selected were divided into normal control group and high dose group（3.0 g/kg）.The level of blood glucose was determined after being given milk powder containing chromium and propolis and distilled water by intragastrical gavage for 30 days continuously.Results：Significant differences were observed between high dose group and diabetic group in fasting blood glucose,postchallenge blood glucose at 2 hour and area under the curve of blood glucose.Milk powder containing chromium and propolis had no effects on fasting blood glucose of normal mice.Conclusion：Milk powder containing chromium and propolis can reduce the level of blood glucose in experimental diabetic mice under this experimental condition.

关 键 词：铬 蜂胶 血糖 糖尿病 小鼠 

分 类 号：R-332[医药卫生]