蔗糖铁治疗维持性血液透析患者贫血的疗效与安全性分析  

Curative Effect and Security Analysis of Treatment of Maintenance Hemodialysis Patients' Anaemia with Iron Saccharate

作　　者：段晓星[1] 张国光[1] 梦雅平[1] 

机构地区：[1]内蒙古医学院附属医院肾脏内科,内蒙古呼和浩特010050

出　　处：《内蒙古医学杂志》2010年第3期294-297,共4页Inner Mongolia Medical Journal

摘　　要：目的:比较静脉用蔗糖铁与口服琥珀酸亚铁分别联合应用促红细胞生成素(EPO)治疗维持性血液透析患者肾性贫血的疗效与安全性。方法:将36例维持性血液透析存在肾性贫血的患者分成两组,静脉组应用蔗糖铁注射液,口服组应用琥珀酸亚铁片,两组均同时用EPO治疗;观察两组患者治疗第4周及第8周血红蛋白(Hb)、红细胞压积(HCT)、血清铁、铁蛋白(SF)、转铁饱和度(TSAT)、EPO用量并观察两组不良反应的出现。结果:治疗后Hb、HCT、血清铁、SF、TSAT两组均有升高,静脉组比口服组升高差异有统计学意义(p<0.05),且上升速度快于口服组;不良反应少于口服组。结论:静脉用蔗糖铁治疗维持性血液透析患者肾性贫血安全有效。Objective：To compare curative effect and security of treatment of maintenance hemodialysis patients＇ renal anaemia with intravenous iron saccharate and oral ferrous succinate combined with human erythropoietietin separately.Methods： 36 maintenance hemodialysis patients having renal anaemia were divided into two groups.The intravenous group patients were treated with ferrous saccharose injection.The oral group patients were treated with ferrous succinate tablets.All of the two group patients were treated with EPO.Hemoglobin（Hb）,hematocrit（HCT）,serum iron,ferritin（SF）,transferrin saturation（TSAT） and dosage of EPO were observed when the two group patients were treated at the 4th week and at the 8th week.Appearance of adverse reaction of the two group patients was observed.Results： Hb,HCT,serum iron,SF and TSAT of both two group patients were increased.There was statistic significance for difference between increase of the intravenous group and that of the oral group.And the speed of increase of the intravenous group was faster than that of the oral group.The adverse reaction of the intravenous group was less than that of the oral group.Conclusion： It is secure and effective to treat maintenance hemodialysis patients＇ renal anaemia with intravenous iron saccharate.

关 键 词：蔗糖铁 贫血 血液透析 

分 类 号：R734.2[医药卫生—肿瘤]