双花华蟹甲草化学成分的研究  

Chemical constituents from Sinacalia davidii

作　　者：蓝晓聪[1] 武海波[1] 王文蜀[1] 

机构地区：[1]中央民族大学生命与环境科学学院,北京100081

出　　处：《中国中药杂志》2010年第8期1001-1003,共3页China Journal of Chinese Materia Medica

基　　金：中央民族大学"111引智工程"项目(B08044);中央民族大学"985"工程项目(CUN985-03-03);中央民族大学青年教师重点项目(CUN10A);北京市教育委员会科技成果转化与产业化项目

摘　　要：目的:研究我国特有植物双花华蟹甲草Sinacalia davidii化学成分。方法:利用硅胶色谱和Sephadex LH-20色谱手段进行分离纯化,应用NMR等方法鉴定结构。结果:从双花华蟹甲草中分离得到6个化合物,分别鉴定为β-谷甾醇(1),3-氧-2,α23-二羟基-齐敦果-12-烯-28-酸(2),28-羟基-齐敦果-12-烯-3,11-二酮(3),3α-甲氧基-齐敦果-11-酮-18-烯(4),木犀草素(5)和2α-羟基乌索酸(6)。结论:以上6个化合物均为首次从双花华蟹甲草中分离得到。Sinacalia davidii（Franch） Koyama.grows only in China,its chemical constituents have never been studied before.The compounds were isolated by column chromatography on silica gel and Sephadex LH-20,and the structures were identified on spectroscopic data（MS,1H-NMR,13C-NMR）.Six compounds were isolated from S.davidii,and were characterized as β-sitosterol（1）,3-oxo-2α,23-dihydroxy-olean-12-en-28-oic acid（2）,28-hydroxy-olean-12-en-3,11-dione（3）,3β-methoxy-olean-11-oxo-18-ene（4）,luteolin（5） and 2α-hydroxy-ursolic acid（6）.All the six compounds above were isolated from S.davidii for the first time.

关 键 词：华蟹甲属 双花华蟹甲草 五环三萜 黄酮 甾醇 

分 类 号：R284[医药卫生—中药学]