HER-2、E-cadherin在非小细胞肺癌中联合表达的意义  

The significance of HER-2 and E-cadherin expression in non-small cell lung carcinoma

作　　者：卢洪胜 王双珠[2] 周涛[2] 蔡菊芳[2] 甘梅富[2] 

机构地区：[1]浙江省台州市恩泽医疗中心(集团)台州中心医院病理科,318000 [2]浙江省台州市恩泽医疗中心(集团)台州医院病理科,317000

出　　处：《实用医学杂志》2010年第7期1154-1156,共3页The Journal of Practical Medicine

摘　　要：目的:探讨人表皮生长因子受体-2(HER-2)和E-钙黏蛋白(E-cadherin)在人非小细胞肺癌组织中联合表达的意义。方法:采用EnVision免疫组织化学技术检测89例肺癌组织及48例对照组织中HER-2和E-cadherin的表达状况。结果:(1)对照组与肺癌组中HER-2和E-cadherin的总阳性率分别为0、70.8%和95.8%、49.4%,组内比较差异具有显著性(P<0.05);(2)HER-2在肺癌的淋巴结转移及TNM分期组阳性率分别递增,其差异具有统计学意义(P<0.05),E-cadherin在肺癌组织分化程度、淋巴结转移及TNM分期组阳性率分别递减,其差异具有统计学意义(P<0.05);(3)HER-2阳性表达与E-cadherin阳性表达呈负相关,其差异具有统计学意义(P<0.05)。结论:HER-2高表达和E-cadherin的低表达在非小细胞肺癌的发生、恶性演进过程中起作用,联合应用HER-2和E-cadherin可以判断肺癌的转移潜能及预后。Objective To investigate the co-expression of HER-2 and E-cadherin in non-small cell lung cancer （NSCLC）. Methods HER-2 and E-cadherin expression was were detected using immunohistochemistry method （EnVision） in 89 cases of cervical cancer and 48 cases of control lung tissues. Results （ 1 ）The positive rate of HER-2 and E-cadherin in NSCLC was 70.8% and 49.4%, respectively. Significant difference exited between the normal group and NSCLC group （P 〈 0.05）. （2）HER-2 expression was significantly increased in groups of high-level lymphonode metastasis and TNM staging （P 〈 0.05）. However, E-cadherin expression was significantly decreased in groups of high-level histologieal differentiation, lymphonode metastasis and TNM staging （P 〈 0.05）. （3）Significant correlation exited between HER-2 and E-cadherin expression. Conclusions Up-regulation of HER-2 and down-regulation of E-eadherin may contribute to NSCLC invasion and metastasis. HER-2 and E-eadherin detection may serve as a marker for lymph node metastasis of NSCLC and prognosis of patients with NSCLC.

关 键 词：癌 非小细胞肺 HER-2 上皮型钙粘蛋白 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]