改良溶栓方案治疗解剖变异的脑静脉窦血栓形成  

A modified thrombolytic scheme for the treatment of thrombosis in anatomically varied cerebral venous sinus

作　　者：赵林[1] 李林芳[1] 刘增品[1] 秦会敏[1] 王铁刚[1] 周存河[1] 

机构地区：[1]河北医科大学第二医院医学影像科,石家庄050000

出　　处：《介入放射学杂志》2010年第3期174-176,共3页Journal of Interventional Radiology

基　　金：河北省科学技术研究与发展计划资助项目(052761605)

摘　　要：目的探讨静脉窦内微量持续泵滴注尿激酶(10万u/24h)治疗解剖学变异的脑静脉窦血栓形成的疗效。方法对9例患者进行机械性碎栓、静脉窦内留置微导管行最低量尿激酶10万u/24h静脉窦直接泵滴注48～96h治疗。术后积极治疗原发病,抗凝治疗6个月。术后随访6～12个月,平均10个月。结果9例解剖学变异脑静脉窦血栓形成患者,脑静脉窦均获得再通(其中8例患者应用尿激酶10万u/24h效果良好,1例患者在应用尿激酶10万u/24h,48h复查后增量至25万u/24h),预后良好。结论静脉窦内微量持续泵滴注尿激酶可有效治疗解剖学变异脑静脉窦血栓形成。Objective To discuss the curative effect of unremitting pump infusion of microdose urokinase （100 000 u / 24 h） into the cerebral venous sinus in treating thrombosis in cerebral venous sinus which had anatomical variation. Methods Mechanical disruption of the thrombus and unremitting pump infusion of microdose urokinase （100 000 u / 24 h） into the cerebral venous sinus for 48-96 hours were employed in 9 patients with thrombosis in anatomically varied cerebral venous sinus. After the procedure the original disorder was actively treated and the anticoagulant therapy was continued for 6 months. A follow-up of 6-12 months （mean 10 months） was conducted. Results Recanalization of the previously occluded cerebral venous sinus was obtained in all 9 patients. The dose of urokinase was 100 000 u / 24 h in 8 patients. For the remaining one patient the dose of urokinase was 100 000 u / 24 h in the first 48 hours, then the dose was increased to 250 000u / 24 h. Excellent result was obtained in all patients. Conclusion Unremitting pump infusion of microdose urokinase into the cerebral venous sinus can effectively treat the thrombosis in anatomically varied cerebral venous sinus.

关 键 词：静脉窦 解剖学变异 溶栓 介入 尿激酶 微量 

分 类 号：R743.3[医药卫生—神经病学与精神病学]