口腔鳞癌中VEGF-C的表达及与颈淋巴转移的关系  

Relationship between the expression of VEGF-C and neck lymphatic metastasis in oral squamous cell carcinoma

作　　者：黄元清 宋宇峰[2] 张建国 

机构地区：[1]岳阳市第二医院口腔外科,湖南岳阳414000 [2]贵阳医学院附属医院口腔颌面外科,贵州贵阳550004

出　　处：《临床口腔医学杂志》2010年第3期145-147,共3页Journal of Clinical Stomatology

基　　金：国家自然科学基金(30660200);贵州省优秀科技教育人才省长专项基金(2005-160)

摘　　要：目的:检测口腔鳞癌(OSCC)中血管内皮生长因子-C(VEGF-C)的表达,以探讨VEGF-C与OSCC淋巴转移的关系及其临床意义。方法:应用免疫组织化学染色(S-P法)检测40例OSCC组织及14例正常口腔黏膜组织中VEGF-C的表达情况。结果:45.0%的OSCC组织中可见VEGF-C表达,在正常口腔黏膜中无表达;22例伴淋巴结转移的OSCC组织中,68.2%有VEGF-C表达,18例不伴有淋巴结转移者,16.7%有VEGF-C表达,两组之间差异有统计学意义(P<0.01);16.7%的Ⅰ～Ⅱ期OSCC有VEGF-C表达,57.1%的Ⅲ～Ⅳ期OSCC有VEGF-C表达,两者之间差异有统计学意义(P<0.05);与肿瘤的部位、年龄及性别无关(P>0.05)。结论:VEGF-C在OSCC组织中表达明显上调,并与淋巴管生成、颈淋巴结转移及TNM分期等临床病理生物学行为有关,提示VEGF-C可能在OSCC的生长及转移中起重要作用。Objective：To detective the relationship between vascular endothelial growth factor-c（VEGF-C）and lymphatic metastasis in oral squamous cell carcinoma（OSCC）and its clinical significance through observing the expression of VEGF-C in OSCC.Method：SP immunohistochemical technique was performed for detecting the expression of VEGF-C in 40 OSCC tissues and 14 normal oral mucosa tissues.Result：The positive rate of VEGF-C protein in OSCC was 45.0 % and not observed in normal oral mucosa.In the group with lymph node metastasis and the group without lymph node metastasis,the positive rate of VEGF-C protein expression was 68.2% and 16.7% respectively.There were significant differences between the two groups（P 0.01）.The positive rate of VEGF-C protein was 16.7% in theⅠ～Ⅱstage.The positive rate of VEGF-C protein was 57.1 % in the Ⅲ～Ⅳstage.There were significant differences between the two groups（P 0.05）.But there were no significant differences with patients＇position,age or sex（P 0.05）.Conclusion：Overexpression of VEGF-C protein was involved in development of OSCC and correlated with clinicopathological features such as Lymphangiogenesis、 neck lymph node metastasis and TNM stage.

关 键 词：口腔鳞癌 血管内皮生长因子-C 淋巴结转移 

分 类 号：R780.2[医药卫生—口腔医学] R739.8[医药卫生—临床医学]