ALOX5AP基因SG13S114A／T多态性与颈动脉粥样硬化斑块稳定性的相关性  

Association of the ALOXSAP gene SG13S114 A/T polymorphism with atherosclerosis

作　　者：何颖蕾[1] 金笑平[1] 朱敏[2] 林仙方[3] 谢宗林[4] 陈秋月[1] 

机构地区：[1]台州医院神经内科,浙江省台州市317000 [2]台州医院中心实验室,浙江省台州市317000 [3]台州医院超声科,浙江省台州市317000 [4]台州医院特需病房,浙江省台州市317000

出　　处：《中华医学遗传学杂志》2010年第2期186-189,共4页Chinese Journal of Medical Genetics

基　　金：2008年浙江省医药卫生科学研究基金（20088199）;浙江省自然科学基金（Y2080618）

摘　　要：目的探讨花生四烯酸5-脂氧合酶激活蛋白（arachidonate 5-lipoxygen aseactivating protein，ALOX5AP）基因SG13S114A／T的多态性与颈动脉粥样硬化斑块稳定程度的关系。方法应用聚合酶链反应-限制性片段长度多态性分析法检测132例颈动脉易损斑块及152例稳定斑块的急性脑梗死者ALOX5AP基因SG13S114A／T基因型，比较两组间该位点多态性的差异。结果易损斑块组ALOX5AP基因SG13S114AA基因型和A等位基因频率高于稳定斑块组，两组差异有统计学意义（P〈0．01），其中男性和女性上述基因型和等位基因频率的比较，易损斑块组均高于稳定斑块组，两组差异有统计学意义（P〈0．01）。结论ALOX5AP基因SG13S114A／T多态性可能与动脉粥样斑块的稳定性有关，其中SG13S114A等位基因可能是易损斑块的风险因素。Objective To investigate the relationship between the polymorphism of SG13Sl14 A/T in the 5-1ipoxygenase-activating protein （ALOX5AP）gene and the stability of carotid atherosclerosis. Methods Polymorphism of SG13S114 A/T in the ALC）X5AP gene was analyzed in 152 cases of acute infarction with stable plaque, and 132 cases of acute infarction with vulnerable plaques, by using polymerase chain reaction and restriction fragment length polymorphism. Carotid artery plaque was analyzed by carotid artery color ultrasound. Results The frequencies of SG13S114 AA genotype and the A allele in the vulnerable plaque group were higher than that in the stable plaque group （P〈0. 01）. Conclusion The polymorphism of SG13S114 A/T in the ALOX5AP gene may be associated with the instability of atberosclerosis. And the SG13S114 A allele may be a risk factor of vulnerable plaques.

关 键 词：5-脂氧合酶激活蛋白 动脉粥样硬化 遗传多态性 聚合酶链反应 

分 类 号：R743[医药卫生—神经病学与精神病学]