降低氯化锂-匹罗卡品大鼠癫痫模型死亡率的实验研究  

Experimental study on the mortality of reducing the epilepsy rat model induced by LiCl-pilocarpine

作　　者：王冬梅[1] 孙艺平[1] 徐静[1] 徐红[1] 赵赫男[2] 李骢[2] 宫德正[1] 田余祥[3] 

机构地区：[1]大连医科大学机能实验室,辽宁大连116044 [2]大连医科大学病理生理教研室,辽宁大连116044 [3]大连医科大学生化教研室,辽宁大连116044

出　　处：《大连医科大学学报》2010年第2期176-178,共3页Journal of Dalian Medical University

摘　　要：[目的]探讨有效控制氯化锂-匹罗卡品诱发癫痫持续状态,提高癫痫大鼠存活率的最佳条件。[方法]选用SD大鼠30只,腹腔注射氯化锂和匹罗卡品后,诱发大鼠癫痫持续状态1 h后,随机分为A组：只给东莨菪碱;B组：东莨菪碱＋安定;C组：东莨菪碱＋水合氯醛。比较3组大鼠间癫痫发作的持续状态、癫痫大鼠的死亡率、死亡发生的时间。[结果]A组大鼠癫痫发作的持续状态为16-20 h,死亡率为87.5%;B组大鼠在用药后15 min内可控制癫痫发作的持续状态,死亡率为62.5%;C组大鼠在用药后3-10 min可完全控制大鼠的癫痫发作持续状态,大鼠全部存活。[结论]水合氯醛可有效控制氯化锂-匹罗卡品诱发大鼠的癫痫持续状态,提高癫痫大鼠的存活率。[Objective]To explore the effective control of persisting epilepsy status induced by LiCl-pilocarpine and the optimal condition of reducing the death rate of these animals.[Methods]Thirty SD rats were injected with LiCl-pilocarpine intraperitoneally to induce their persisting epilepsy status.One hour later,they were randomly divided into group A only administrated with scopolamine,group B with scopolamine and diazepam,and group C with scopolamine and chloral hydrate.The indexes including the rats epilepsy plexy persisting status,mortality,and death time were observed and compared respectively.[Results]The epilepsy plexy persisting status of the rats in group A was lasting for 16 to 20 hours with the death rate of 87.5%.The persisting status of the rats in group B was controlled within 15 minutes with the death rate of 62.5 %.The symptom of the animals in group C was completely controlled within 3 to 10 minutes after administration and all the rats survived.[Conclusion]Chloral hydrate could effectively control the experimental rat s epilepsy persisting status and decrease the their mortality.

关 键 词：氯化锂-匹罗卡品 癫痫 水合氯醛 死亡率 

分 类 号：R742.1[医药卫生—神经病学与精神病学]