西安及深圳地区鼻咽癌组织中MMP-9和TIMP-1的表达及意义  

Expression of MMP-9 and TIMP-1 in nasopharyngeal carcinoma and its signification at Xi'an and Shenzhen

作　　者：王鸿雁[1] 景雅曼[2] 郑建杰[3] 王敏[1] 

机构地区：[1]西安交通大学第一附属医院病理科,西安710061 [2]深圳市第二人民医院耳鼻咽喉科 [3]西安交通大学第一附属医院心脏外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2010年第7期296-298,共3页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:探讨鼻咽癌组织中基质金属蛋白酶9(MMP-9)和基质金属蛋白酶组织抑制剂-1(TIMP-1)的表达在陕西西安与深圳地区之间是否存在地域差别及其意义。方法:应用免疫组织化学方法分别检测西安地区21例、深圳地区22例鼻咽癌组织中MMP-9和TIMP-1表达的情况。结果:西安与深圳地区鼻咽癌组织中MMP-9阳性表达率分别为61.90%和68.18%;TIMP-1阳性表达率两地区分别为28.57%和31.82%。两地区鼻咽癌组织中MMP-9与TIMP-1表达均有显著负相关性。西安地区MMP-9表达与淋巴结转移有显著关系,TIMP-1则与淋巴结转移无相关性。两地区之间MMP-9、TIMP-1的表达差异无统计学意义(P>0.05)。结论:鼻咽癌组织中MMP-9、TIMP-1的表达在西安与深圳两地区之间无差别;MMP-9高表达在鼻咽癌浸润转移中有重要作用。Objective：To compare the expression of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 of nasopharyngeal carcinoma at Xi＇an and Shenzhen area.Method：The protein expression of MMP 9 and TIMP 1 were studied by immunohistochemisty staining in 21 cases nasopharyngeal carcinoma of Xi＇an and 22 cases of Shenzhen.Result：The expression positive rates of MMP-9 in nasopharyngeal carcinoma tissues at Xi＇an and Shenzhen were 61.90% and 68.18%.The positive rates of TIMP-1 in nasopharyngeal carcinoma tissues at two regions were 28.57% and 31.82%. The expression between MMP-9 and TIMP-1 were negative relationship either Xi＇an or Shenzhen. The expression of MMP-9 was positively correlated to lymph node metastasis, and TIMP-1 was no relationship with lymph node metastasis. The expression of MMP-9 and TIMP-1 was no difference between Xi＇an and Shenzhen.Conclusion：The expression of MMP-9 and TIMP-1 in nasopharyngeal carcinoma tissues was no difference between Xi＇an and Shenzhen. Increase of MMP-9 play an important role in progression and metastasis of nasopharyngeal carcinoma.

关 键 词：鼻咽肿瘤 基质金属蛋白酶9 基质金属蛋白酶组织抑制剂-1 免疫组织化学 

分 类 号：R739.63[医药卫生—肿瘤]