血清脂联素的表达及肝功能、肝脾CT值等联合检测对非酒精性脂肪肝诊断的临床意义  

The clinical significance of adiponectin expression and its diagnostic value combined with liver function tests and liver/spleen CT value in Non-alcoholic fatty liver disease

作　　者：许腊梅[1] 孙丹莉[1] 张予蜀[1] 张振玉[1] 袁捷[1] 杜同信[2] 

机构地区：[1]南京医科大学附属南京第一医院消化科,江苏南京210006 [2]南京医科大学附属南京第一医院放免中心,江苏南京210006

出　　处：《临床肝胆病杂志》2010年第2期170-172,共3页Journal of Clinical Hepatology

基　　金：南京市卫生局资助项目(YKK05076)

摘　　要：目的探讨血清脂联素的表达及肝功能、肝脾CT值等联合检测对非酒精性脂肪性肝病(NAFLD)诊断的临床意义。方法选取NAFLD患者71例,分为轻、中、重三组;对照组41例。检测ALT、AST、GGT、TG、TC、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及脂联素,分析脂联素与各临床指标的相关性,NAFLD组与对照组、NAFLD不同组间上述指标的变化。结果(1)与对照组比较,NAFLD组的脂联素水平、肝脏CT值、CT肝脾比值、HDL-C明显降低(P<0.01),BMI、ALT、AST、TG、TC、GGT、LDL-C明显增高(P<0.01);(2)脂联素与BMI、ALT、AST、GGT、LDL-C呈负相关,与肝脏CT值、HDL-C呈正相关;(3)ALT在轻度与中度、轻度与重度组间表达有统计学意义(P<0.05),而中度与重度组间差异表达无统计学意义(P>0.05)。结论联合检测脂联素、ALT对于NAFLD的诊断和鉴别诊断有临床意义。Objective To evaluate the expression of adiponectin and its clinical significance in combination with liver function tests and liver/spleen CT value in patients with Non-alcoholic fatty liver disease（NAFLD）.Methods 71 NAFLD patients and 41 controls were enrolled in this study.The NAFLD patients were divided into mild,moderate and severe groups.ALT,AST,GGT,TG,TC,HDL-C,LDL-C and adiponectin levels were measured.The correlation between adiponetin and these factors were analyzed.Results Serum adiponectin levels,liver CT values,the CT ratio of liver and spleen were significantly lower in patients with NAFLD compared to the control group （P0.01）.The values of BMI,ALT,AST,TG,TC,GGT and LDL-C were significantly increased in patients with NAFLD compared to the control group（P0.01）.Adiponectin was significantly negatively correlated with BMI,ALT,AST,GGT and LDL-C,and positively correlated with CT and HDL-C values.The ALT level was significantly different between the mild and moderate,and the mild and severe NAFLD groups （P0.05）,and was not significantly different between the moderate and severe groups （P0.05）.Conclusion Adiponectin,when combined with ALT,has a significant clinical value in the diagnosis and differential diagnosis of NAFLD.

关 键 词：非酒精性脂肪肝 脂联素 ALT 

分 类 号：R575.5[医药卫生—消化系统]