氯己定局部缓释系统辅助龈下刮治和根面平整效果的Meta分析  

Meta analysis on effect of local application of chlorhexidine with scaling and root planing

作　　者：林莉[1] 李晓燕[1] 梁丽云[1] 姜晓佳[1] 李喆[1] 潘亚萍[1] 

机构地区：[1]中国医科大学口腔医学院口腔内科,辽宁沈阳110002

出　　处：《上海口腔医学》2010年第2期124-128,共5页Shanghai Journal of Stomatology

基　　金：辽宁省教育厅资助项目(20061021)~~

摘　　要：目的:比较并评价在慢性牙周炎治疗过程中,牙周袋内应用氯己定局部释药系统辅助龈下刮治和根面平整(scaling and root planing,SRP)的临床效果是否优于单纯SRP。方法:主要检索6个数据库,一些全文通过手工检索获得。收集至2009年5月公开发表的中英文牙周局部应用氯己定释药系统辅助龈下刮治和根面平整的随机对照试验,随访时间至少3个月。观察指标为术后牙周探诊深度(probing depth,PD)的减少和临床附着水平(clinical attachment level,CAL)的增加。结果:最终有7个研究纳入本系统评价。Meta分析结果显示,牙周局部应用氯己定释药系统辅助SRP与单纯SRP相比,可以使PD显著降低,而CAL在2个治疗组间无统计学差异。结论:在慢性牙周炎的治疗过程中,牙周局部应用氯己定释药系统辅助SRP可以使牙周探诊深度显著降低。PURPOSE：Meta analysis was used to assess the effect of local drug delivery system of chlorhexidine （CHX） as an adjunct to scaling and root planing（SRP） versus SRP alone in patients with chronic periodontitis. METHODS：The selected studies of randomized controlled trials （RCTs） were pooled from six major electronic database up to May,2009 as CHX plus SRP versus SRP with at least 3 months of follow-up. Several English full texts were hand searched. Outcome measures were probing depth（PD） reduction and clinical attachment level （CAL）gain. RESULTS：Seven studies that met inclusion criteria were entered into the Meta analysis. A significant mean reduction of PD in patients with CHX plus SRP was observed,but there were no significant difference in CAL between the two treatment groups. CONCLUSIONS：Chlorhexidine as an adjunct to SRP could reduce probing depth in the treatment of chronic periodontitis.

关 键 词：牙周炎 刮治 根面平整 氯己定 META分析 

分 类 号：R781.4[医药卫生—口腔医学]