PHE/TYR比值在新生儿苯丙酮尿症筛查中的应用  

The application of PHE/TYR Ration in Neonatal Screening for Phenylketonuria

作　　者：孙明强[1] 张鲁明[1] 董天亮[1] 周玉兰[1] 田维兵[1] 徐雁[1] 刘金龙[1] 

机构地区：[1]潍坊市妇幼保健院,山东潍坊261011

出　　处：《医学检验与临床》2010年第1期22-23,共2页Medical Laboratory Science and Clinics

摘　　要：目的 分析Phe/Tyr比值在新生儿苯丙酮尿症筛查中的作用.方法 采用API-300 SPOTCHECK连续流动荧光分析系统检测1103例正常新生儿的筛查血片和27例已经确诊的PKU阳性患儿血片的Phe和Tyr值,并进行分析.结果 API-300 SPOTCHECK连续流动荧光分析法的阳性复合率为103.7%,阴性复合率为99.9%.结论 Phe/Tyr 比值是提高PKU筛查准确度的重要参数.Objective To analyze the role of PHE/TYR ratio in neonatal screening for phenylketonuria. Methods Using the API 300 SPOTCHECK continue flow fluorescence analyzer system to detect Phe and Tyr of 1130 normal newborn cases and 27 PKU positive cases, Analyse the data. Result the positive coincidence rate is 103.7%, and the negative coincidence rate is 99.9%. Concolusion Phe/Tye ratio is a more reliable indicator for detecting PKU.

关 键 词：苯丙酮尿症 筛查 

分 类 号：R722.1[医药卫生—儿科]