晚期孕妇血浆APTT、PT、FIB和D-二聚体水平的检测及临床意义  

Clinical significance of plasma level changes of activated partial thrombyplastin time,prothrombin time,fibrine-genin and D-dimer in advanced stage pregnant women

作　　者：刘芳[1] 王小刚[1] 

机构地区：[1]怀化市中医院,湖南怀化418000

出　　处：《医学检验与临床》2010年第1期36-37,共2页Medical Laboratory Science and Clinics

摘　　要：目的 探讨晚期孕妇凝血和纤溶功能变化与妊娠期高血压疾病的关系.方法 随机选取我院79例待产孕妇,检测其血浆凝血三项（APTT、PT、FIB）和D-二聚体水平,以71例非妊娠妇女作对照.结果 待产孕妇组APTT和PT明显低于非妊娠组,FIB和D-二聚体水平明显高于非妊娠组（P〈0.01）.而正常妊娠组与妊高征组PT、APTT、FIB和D-D比较,妊高征组PT、APTT时间明显缩短,FIB和D-D明显增高,且差异有显著性（P〈0.01）.结论 晚期孕妇血液处于高凝状态,产前凝血功能和纤溶指标的检测对预防产科并发症具有一定的指导意义.Objective To explore the relation between the changes of Coagulation and Fibrinolysis function and hypertensive disorders in pregnancy inadvanced stage pregnant women.Methods The study randomly enrolled 79 prepartal women and 71 non- pregnant women as con- trol. Acti - vated partial thromboplastin time（ AFIT）, prothrombin time（PT）, fibri - nogenln（FIB） and D - dimer（ D - D） were measured. Resuits The plasma level of APTT and PT of Drepartal women was significantly lower than those of non - pregnant women（P 〈 0.01 ）. The plasma levels of D - dimer（ D - D） and Fib of pregnant women was significantly higher than those of non - pregnant women（P 〈 0.01 ）. And comparing the pregngnancy group with the normal pregnancy group, PT,AFIT were significantly reduced and FIB,D- D were contrary（P 〈 0.01）. Conclusion The blood in advanced stage pregnant women was in the hypercoagulable state. The detection of blood conertion founction and fibrinolytic system play an improntant role in the prevention complications.

关 键 词：孕妇 凝血功能 纤溶功能 D-二聚体 

分 类 号：R743.33[医药卫生—神经病学与精神病学]