羟磷灰石结合蛋白和小分子多肽的研究进展  

Research progress of hydroxyapatite binding proteins and peptides

作　　者：魏蔚[1] 刘燕[1] 毛靖[1] 周彬[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院口腔医学中心,湖北武汉430030

出　　处：《国际口腔医学杂志》2010年第2期163-165,共3页International Journal of Stomatology

基　　金：国家自然科学基金资助项目(30700957;30870651)

摘　　要：羟磷灰石(HA)是骨组织和牙体硬组织中的主要无机成分,在生物体内存在多种能与HA结合的蛋白质。一些蛋白质能特异性地识别HA晶体表面的某些特殊结构,并在生物矿化过程中扮演重要角色。近年来,通过分子模拟技术和分子生物学技术相结合的方法,人们采用噬菌体表面展示技术对有机—无机界面的分子识别进行了研究,极大地推动了HA结合小分子多肽的分离和界面识别机制研究,HA结合的小分子多肽在生物矿化调控和新材料合成方面展现了广泛的应用前景。下面就HA结合蛋白和小分子多肽的研究进展作一综述。There are many natural protein able to bind to hydroxyapatite crystal.Some of these macromolecules recognize the special structure of the crystal surface and play an important role in biomineralization.However,the exact mechanism of the interfacial recognition and how macromolecules govern hard-tissue formation are still unknown.Recently,combinations of biomimetics and molecular biology have been developed to understand the recognition between macromolecules and inorganic surface,which might stimulate the research of new biomaterials.Here we review recent studies that have revealed the recognition at the protein-hydroxyapatite or peptide-hydroxyapatite interface.

关 键 词：羟磷灰石 结合蛋白 多肽 噬菌体表面展示 

分 类 号：R318.0[医药卫生—生物医学工程]