大果沙棘黄酮对糖尿病小鼠血脂与抗氧化水平的影响  

Hypolipidemic and Antioxidant Effects of Flavonoids from Hippophae rhamnoides L.Pomace in ICR Mice with Alloxan Induced Diabetes

作　　者：王振宇[1,2] 刘瑜[1] 周丽萍[1] 

机构地区：[1]东北林业大学林学院,黑龙江哈尔滨150040 [2]哈尔滨工业大学食品科学与工程学院,黑龙江哈尔滨150001

出　　处：《食品科学》2010年第7期297-301,共5页Food Science

基　　金：黑龙江省科技攻关项目(GB06B404-1)

摘　　要：目的:研究大果沙棘黄酮对四氧嘧啶(ALX)诱导的糖尿病小鼠的血脂及抗氧化水平的影响。方法:用ALX制造糖尿病小鼠模型,大果沙棘黄酮(SBPF)分为低(3.0(mg/kgbw·d))、中(30.0mg/(kgbw·d))、高(90.0(mg/kgbw·d))3个剂量组,连续灌胃4周。结果:与模型组相比,BFH能极显著地降低ALX诱导的糖尿病小鼠血糖水平、血脂水平、丙二醛(MDA)和尿素氮(BUN)含量,提高胰岛素水平、肝(肌)糖元含量,提高超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、麦芽糖酶(CAT)活性,增强机体抗氧化能力,同时可调节糖尿病小鼠的饮食水平。结论:SBPF能有效的控制糖尿病小鼠血糖水平、血脂水平,提高小鼠机体抗氧化能力。To examine the potential hypolipidemic and antioxidant effects of flavonoids from sea buckthorn（Hippophae rhamnoides L.） pomace（SBPF） in ICR mice with diabetes,healthy IR mice were used as experimental animals to create an alloxan（ALX） induced diabetic model.Mice with ALX induced diabetes were randomly divided into 4 groups including model control group administered normal saline by gavage and SBPF groups administered low,medium and high doses of SBPF aqueous solution at the same volume as normal saline by gavage.Additional healthy IR mice were served as normal control group and also administered normal saline by gavage like the model control group.All the groups were administered once a day for 4 consecutive weeks.Results showed that compared with the model control group,the three SBPF groups exhibited significantly lowered serum glucose,blood liquid,MDA and BUN levels,elevated insulin and glycogen levels and SOD,GSH-PX and CAT activities,and enhanced antioxidant function and diet level.In conclusion,SBPF administration not only effectively regulates the levels of serum glucose and blood lipid,but also enhances antioxidant function in diabetic mice.

关 键 词：沙棘黄酮 糖尿病 血糖 血脂 抗氧化 

分 类 号：R282.7[医药卫生—中药学]