多烯磷脂酰胆碱联合阿托伐他汀治疗酒精性肝病的临床观察  

Clinical Observation of Polyene Phosphatidyl Choline Combined with Atorvastatin for Alcoholic Liver Disease

作　　者：刘宇红[1] 才洪良[1] 穆丽雅[1] 

机构地区：[1]哈尔滨242医院消化内科,哈尔滨市150066

出　　处：《中国药房》2010年第16期1474-1476,共3页China Pharmacy

摘　　要：目的:探讨多烯磷脂酰胆碱联合阿托伐他汀治疗酒精性肝病的临床疗效及其安全性。方法:112例酒精性肝病患者随机分成2组,各56例,对照组予戒酒及多种维生素治疗并加用多烯磷脂酰胆碱(465mg,qd,静脉滴注);治疗组在对照组基础上加服阿托伐他汀片(10mg,每晚睡前口服1次)。2组疗程均为4周。观察2组治疗前、后临床症状、体征、肝功能、血脂的变化情况。结果:治疗组患者的临床症状、体征、肝功能、血脂的改善明显优于对照组(P<0.05),2组均未见明显不良反应。结论:多烯磷脂酰胆碱联合阿托伐他汀治疗酒精性肝病疗效确切,不良反应少。OBJECTIVE：To observe the therapeutic efficacy and safety of polyene phosphatidyl choline and atorvastatin in the treatment of alcoholic liver disease. METHODS：112 patients with alcoholic liver disease were randomly divided into control group （n=56）and treatment group（n=56）. Both groups were given a cure for alcoholism,vitamin and polyene phosphatidyl choline （465mg,qd,i.v. gtt）therapy. Treatment group were additionally treated with torvastatin（10 mg,po）once a day before bed for 4 weeks. Clinical symptoms,signs,liver function,blood lipid changes of two groups before and after treatment were observed. RESULTS：Treatment group was superior to control group in respect of clinical symptoms,signs,liver function and blood lipid changes（P0.05）. There was no significant adverse reaction in two groups. CONCLUSION：Polyene phosphatidyl choline combined with atorvastatin has remarkable therapeutic effect on alcoholic liver disease with good safety.

关 键 词：多烯磷脂酰胆碱 阿托伐他汀 酒精性肝病 

分 类 号：R575[医药卫生—消化系统]