凋亡抑制蛋白XIAP、Survivin在子宫颈癌组织中的表达及意义  

The Significance and Expression of XIAP and Survivin in Cervical Cancer

作　　者：张珍[1] 周晖[2] 陆晓楣[2] 卢淮武[2] 林仲秋[2] 

机构地区：[1]广东药学院,510006 [2]中山大学附属第二医院妇产科

出　　处：《岭南急诊医学杂志》2010年第2期102-104,共3页Lingnan Journal of Emergency Medicine

基　　金：广东省卫生厅基金资助(B2007057)

摘　　要：目的:比较正常宫颈及宫颈癌组织中凋亡抑制基因XIAP、Survivin的表达,探讨其与宫颈癌发生、发展的关系。方法:应用RT-PCR方法,在20例宫颈癌及癌旁组织中检测XIAP、Survivin的表达情况。结果:Survivin在宫颈癌旁组织中表达阳性率为60%(12/20),在宫颈癌组织中Survivin阳性率为90%(18/20),Survivin mRNA含量在两组中有显著差异(P<0.05)。XIAP在宫颈癌组织和癌旁组织中表达相当,差异无统计学意义(P>0.05)。宫颈癌Survivin mRNA及XIAP mRNA表达与患者临床分期、淋巴结转移、组织分化程度均无显著关系。结论:Survivin可能通过抑制细胞凋亡对宫颈癌的发生、发展起重要作用。Objective： To compare the expression of XIAP and Survivin in cervical cancer tissues and non- cancer tissues to investigate the potential implication of XIAP and Survivin in the development of cervical cancer. Methods： RT-PCR method was used to determine the expression of XIAP and Survivin mRNA in 20 cases of human cervical cancer tissues and non-cancer tissues. Results：The positive rate of Survivin in non-cancer tissue,cervical cancer was 60% and 90% respectively, Survivin mRNA levels of cancer tissues were undetectable or low expression in non-cancer tissues, fully differentiated tissues, and high expression levels were observed in a broad range of cancer tissues. XIAP mRNA levels were similar among control and cancer tissues. There were no significant differences in expression levels of Survivin and XIAP among any of the clinical variables studied. Conclusion： Survivin may play an important role in carcinogenesis of cervical cancer.

关 键 词：子宫颈癌 凋亡抑制蛋白 人乳头瘤病毒 

分 类 号：R737.33[医药卫生—肿瘤]