二苯乙烯苷对AD模型鼠老年斑和行为障碍的影响  

Effect of Tetrahydroxy Stilbene Glycoside on the Memory and Senile Plaque in Rat Model of Alzheimer Disease

作　　者：罗红波[1] 杨金升[1] 石向群[1] 

机构地区：[1]兰州军区兰州总医院神经内科,甘肃兰州730050

出　　处：《现代生物医学进展》2010年第5期872-874,共3页Progress in Modern Biomedicine

摘　　要：目的:观察二苯乙烯苷对Alzheimer病(AD)模型大鼠行为学及脑内海马区域老年斑的影响。方法:采用立体定向仪下于海马部位注射微量Aβ1-42造模,行Y-电迷宫实验检测学习记忆能力及刚果红染色法观察大鼠脑内老年斑的变化。结果:模型组躲避所需的电刺激次数明显增加(29.53±2.28),P<0.05,海马部位老年斑增多(6.87±1.21),P<0.01;二苯乙烯苷干预后,大鼠躲避所需的电刺激次数减少(19.13±2.47),P<0.05,同时,海马部位老年斑减少(4.13±1.19),P<0.05。结论:二苯乙烯苷能改善模型大鼠的学习记忆能力,抑制和清除海马结构中老年斑的沉积。Objective：To observe the effect of Tetrahydroxy stilbene glycoside （TSG） on the behavior and senile plaques in model rats of Alzheimer disease （AD）. Methods：AD models were made by injection of Aβ 1-42 into the hippoeampus under the three-dimensional goniometry. Alteration of the behavior of the model rats were measured by Y-electric maze. Changes of senile plaques were observed with histological measure. Results：In model group, the number of electric-stimulus and SP in hippocampus significantly decreased in model rats （P〈0.05 ,P〈0.01）; after treatment with TSG, it correspondingly decreased in model rats （P〈0.05）. Conclusion： TSG can improve the learning and memory capacity and inhibit SP deposition in hippocampus structure.

关 键 词：ALZHEIMER病 二苯乙烯苷 学习记忆 老年斑 

分 类 号：Q95-3[生物学—动物学] R741[医药卫生—神经病学与精神病学]