纳米金在抗肿瘤研究中的应用  

Application of gold nanoparticles in anticancer research

作　　者：刘文佳[1] 谷小虎[2] 丁轶[2] 张岫美[1] 赵云雪[1] 

机构地区：[1]山东大学医学院药理学研究所,山东济南250012 [2]山东大学化学与化工学院,山东济南250100

出　　处：《现代生物医学进展》2010年第5期982-985,共4页Progress in Modern Biomedicine

基　　金：国家重点基础研究发展规划(973计划)资助项目(2007CB936602)

摘　　要：肿瘤的早期诊断依然是目前需要攻克的难关,现有的抗肿瘤药物因具有较大毒性和缺乏特异性而存在很大的局限性。纳米金能够被多种基团修饰从而获得对肿瘤细胞的靶向性,已成为当前抗肿瘤研究的热点。研究发现纳米金可以通过抑制血管生成、携带抗肿瘤药物以及光热效应等达到肿瘤治疗的目的,同时由于修饰后的纳米金对肿瘤细胞具有靶向性,在肿瘤的早期诊断方面也具有重要的意义。纳米金在体内的分布和代谢与其大小、形态及所带电荷有关,有关纳米金毒性和生物相容性性的评价,还有待于进一步研究。Early diagnosis of cancer remains a conundrum to conquer, and present anticancer drugs suffer great limitation for low specificity and normal cell toxicity. As nanogold can be modified by various groups and thus target to cancer cells, it has been becoming a hotspot in anticancer investigation. Researches have found nanogold participate in cancer therapy by means of anti-angiogenesis, anticancer drugs carrying and photothermal effect. It is also significant in cancer early diagnosis on account of cancer targeting for modificatory nanogold. In vivo distribution and metabolism of nanogold rely on its shape, conformation and electrie charge. The biotoxicity and biocompafible ofnanogold are still not well understood.

关 键 词：纳米金 靶向 肿瘤诊断 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]