氧化应激与阿尔采末病  

Oxidative stress and Alzheimer's disease

作　　者：卓烨烨[1] 张汉霆[1,2] 徐江平[1] 

机构地区：[1]南方医科大学药学院药理学系,广东广州510515 [2]Depts of Behavioral Medicine&Psychiatry and Physiology & Pharmacology,West Virginia University Health Sciences Center

出　　处：《中国药理学通报》2010年第4期435-437,共3页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No30672453;30973518);广东省自然科学基金重点项目(No7117782)

摘　　要：阿尔采末病(Alzheimer’s disease,AD)是一种以进行性认知功能障碍和记忆力损害为主的中枢神经系统退行性疾病。对AD的发病机制存在多种假说,其中氧化应激假说目前越来越受到重视。该文从自由基来源、AD病理特征与氧化应激的关系、相关的动物和临床相关研究、常用抗氧化剂和磷酸二酯酶抑制剂在抗氧化应激方面对AD的治疗作用等,对近年来国内外氧化应激与AD关系的研究进行简要综述。Alzheimer＇s disease（AD）is a progressive neurodegenerative disease characterized by cognition impairment and behavioral abnormalities.While the mechanisms involved in AD remain unclear,various hypotheses have been proposed regarding pathogenesis of AD,among which the oxidative stress hypothesis has attracted more and more attention.In the present article,the relationship between oxidative stress and AD is reviewed,including sources of neuronal oxygen radical generation,the link of oxidative stress to pathogenesis of AD,preclinical and clinical studies of AD,therapeutic effects of antioxidants and phosphodiesterase inhibitors on AD.

关 键 词：阿尔采末病 氧化应激 发病机制 神经元 自由基 抗氧化剂 磷酸二酯酶抑制剂 

分 类 号：R05[医药卫生] R349.1