高血压脑出血患者血清和颅内血肿液中IL-1β、IL-6、TNF-α的含量研究  

Study on the levels of IL-1β,IL-6,and TNF-α in venous serum and hematoma fluid of patients with hypertensive cerebral hemorrhage

作　　者：张明伟[1] 彭俊[1] 刘阳[2] 范秀云[1] 曹相军[1] 袁德良[1] 

机构地区：[1]泸州医学院附属中医院神经外科,四川泸州646000 [2]绵阳市第三人民医院神经外科,四川绵阳621000

出　　处：《中华神经外科疾病研究杂志》2010年第2期138-141,共4页Chinese Journal of Neurosurgical Disease Research

摘　　要：目的通过测定高血压脑出血患者静脉血清及颅内血肿液中白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,探讨这些炎症因子与脑出血病灶及外周血之间的关系。方法在高血压脑出血后24 h,72 h,7 d和14 d取80例高血压脑出血患者静脉血清及血肿液检测IL-1β、IL-6、TNF-α的含量(实验组),并与30例正常体检的患者(对照组)对比。结果高血压脑出血患者血肿液IL-1β、IL-6、TNF-α含量显著高于对照组人群静脉血,并且显著高于实验组患者自身静脉血。实验组患者静脉血清中IL-1β、IL-6、TNF-α含量显著高于对照组人群静脉血清,且病情越重几种炎症因子水平越高。脑出血不同时期静脉血清IL-1β、IL-6、TNF-α含量比较,在72 h最高,此后呈下降趋势。结论高血压脑出血患者IL-1β、IL-6、TNF-α参与了脑出血的炎症反应,是脑出血后脑组织损伤的重要机制之一。Objective To detect the levels of interleukin-1β （IL-1β）, interleukin-6 （IL-6）, and tumor necrosis factor-α （TNF-α） in venous serum and hematoma fluid of patients with hypertensive cerebral hemorrhage and to study the relationship between these cytokines and venous serum and hematoma fluid. Methods The levels of IL-1β, IL-6, and TNF-αin venous serum and hematoma fluid of 80 cases （test group） at 24 h, 72 h, 7 d and 14 d after hypertensive cerebral hemorrhage were measured, and the data were compared with those of 30 normal cases （control group）. Results The levels of IL-1β, IL-1β, and TNF-α in henkatoma of patients with hypertensive cerebral hemorrhage were higher than those in venous serum in test group and normal control group. The levels of IL-1β, IL- 6, and TNF-α in venous serum were significantly higher than those in normal control group, which increased with an increase of severity of patient of condition. When compared the levels of IL-1β, IL-6, and TNF-α at different stages of hypertensive cerebral hemorrhage, the highest levels were detected at 72 h followed by a tendency to decrease. Conclusion IL-1β, IL-6, and TNF-α participate in the inflammatory reaction in hypertensive cerebral hemorrhage, which can be one of significant mechanisms in brain injury after hypertensive cerebral hemorrhage.

关 键 词：高血压脑出血 炎症反应 白细胞介素-1Β 白细胞介素-6 肿瘤坏死因子-Α 

分 类 号：R743.34[医药卫生—神经病学与精神病学]