肺癌组织中CD133和CD105的表达及其临床意义  

Expressions of CD133 and CD105 in lung cancer tissue and their clinical significance

作　　者：程继荣[1] 王淑琴[1] 祖木热提[1] 邹静[1] 

机构地区：[1]新疆医科大学第五附属医院肿瘤中心,乌鲁木齐830011

出　　处：《肿瘤》2010年第4期334-337,共4页Tumor

摘　　要：目的:研究肿瘤干细胞标志物CD133和肿瘤血管内皮细胞标志物CD105在肺癌组织中的表达及其临床意义。方法:用免疫组织化学链霉亲和素-生物素-过氧化物酶复合物(streptavidin-biotin-peroxidase complex,SABC)法检测65例肺癌组织和30例癌旁组织中CD133与CD105的表达情况,分析二者与肿瘤大小、组织学类型、组织分化程度、TNM分期、淋巴结转移和预后的关系。结果:肺癌组织CD133和CD105的阳性表达率高于癌旁组织,分别为69.2%vs26.7%和67.7%vs10.0%,差异有统计学意义(均P<0.05)。有淋巴结转移组的CD133和CD105阳性表达率高于无淋巴结转移组,分别为82.5%vs48.0%和80.0%vs48.0%,差异有统计学意义(均P<0.05)。CD133和CD105的表达与淋巴结转移正相关,Pearson列联系数r分别为0.35和0.32(均P<0.05)。CD133和CD105的表达与肿瘤大小、组织学类型、组织分化程度以及TNM分期无相关性(均P>0.05)。CD133与CD105的表达之间呈正相关,Pearson列联系数r=0.37(P<0.05)。CD133和CD105表达阳性组的术后中位生存期低于阴性组,分别是37个月vs66个月和35个月vs70个月,差异有统计学意义(均P<0.05)。结论:CD133和CD105的表达与肺癌患者的淋巴结转移和预后密切相关,其高表达提示预后不良。Objective：To investigate the expressions of tumor stem cell marker CD133 and tumor vascular endothelial cell marker CD105 in lung cancer tissue and their clinical significance.Methods：Streptavidin-biotin-peroxidase complex（SABC）-immunohistochemical staining was used to detect the expression of CD133 and CD105 in 65 cases of lung cancer tissue and 30 specimens of adjacent non-cancerous tissue.The relationship between the expression of CD133/CD105 and tumor size,histological types,differentiation,TNM stage,lymphoid metastasis,and prognosis were analyzed.Results：The positive expression rates of CD133 and CD105 in lung cancer tissues were significantly higher than those in adjacent non cancerous tissues,respectively（69.2% vs 26.7% and 67.7% vs 10.0%,both P0.05）.The positive expression rates of CD133 and CD105 in the group with lymphoid metastasis were higher than those with non lymphoid metastasis,respectively（82.5% vs 48.0% and 80.0% vs 48.0%,both P0.05）.The expressions of CD133 and CD105 were positively correlated with lymphoid metastasis with Pearson coefficient r of 0.35 and 0.32,respectively（P0.05）.No significant correlation was found between the expression of CD133/CD105 and tumor size,histological types,differentiation degree as well as TNM stage（P0.05）.The expression of CD133 was positively correlated with the expression of CD105 in lung cancer tissue with Pearson coefficient r of 0.37（P0.05）.Postoperative median survival periods of CD133 and CD105-positive group were significantly shorter than the CD133 and CD105-negative groups（37 months vs 66 months,35 months vs 70 months,respectively,both P0.05）.Conclusion：The expression of CD133 and CD105 was associated with lymphoid metastasis and prognosis in patients with lung cancer.Their overexpression implies poor prognosis of lung cancer patients.

关 键 词：肺肿瘤 淋巴转移 预后 抗原 CD133 抗原 CD105 

分 类 号：R734.2[医药卫生—肿瘤]