乳腺癌c-erbB-2的表达及其与临床病理指标的关系  

Relationship between c-erbB-2 expression and clinicopathological parameters in breast cancer

作　　者：盛薇[1] 车向明[1] 单涛[1] 崔熙娟[1] 樊林[1] 张倩[1] 高希涛[1] 

机构地区：[1]西安交通大学医学院第一附属医院普外科,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2010年第3期343-347,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：卫生部课题基金资助(No.WKJ2007-3-001)

摘　　要：目的分析乳腺癌c-erbB-2的表达及其与雌激素受体（ER）、孕激素受体（PR）、腋窝淋巴结、肿瘤大小、病理类型等临床病理指标的关系。方法收集术前未予任何治疗的临床病理资料齐全的原发性乳腺癌病例912例,采用免疫组化法检测c-erbB-2的表达,比较c-erbB-2表达与年龄、肿瘤大小、临床分期、肿瘤部位、绝经状况、腋窝淋巴结、ER、PR、病理类型之间的关系,并结合随访资料分析c-erbB-2的表达是否和预后相关。结果c-erbB-2的阳性率为23%。不同年龄组间c-erbB-2的阳性率差异有统计学意义（P=0.009）,特别是〈35岁组c-erbB-2过表达率高于〉55岁组（P=0.006）;肿块直径〈2 cm、2-5 cm和〉5 cm组间c-erbB-2阳性率差异有统计学意义（P〈0.01）,随肿瘤直径的增加c-erbB-2阳性率增高;腋窝淋巴结无转移、转移1~3个、转移〉3个组间c-erbB-2阳性率差异有统计学意义（P〈0.01）,淋巴结转移〉3个组c-erbB-2的阳性率高于其他两组;ER、PR阴性组c-erbB-2的阳性率高于ER、PR阳性组,差异有统计学意义（P〈0.01）;TMN分期中Ⅲ期c-erbB-2的阳性率高于其他两组,差异有统计学意义（P〈0.05）;在绝经状况、肿瘤部位、病理类型指标中各组c-erbB-2的阳性率无统计学差异。c-erbB-2阳性的乳腺癌患者生存时间明显短于阴性者（P〈0.01）。结论c-erbB-2过表达与肿瘤大小、腋窝淋巴结转移、临床分期呈正相关,与年龄、ERPR呈负相关,与绝经状况、肿瘤部位、病理类型不相关。c-erbB-2是判断乳腺癌预后的良好指标。Objective To observe the expression of c-erbB-2 and its relationships with clinicopathological parameters including estrogen receptor（ER）,progestogen receptor（PR）,axillary lymph node metastasis,tumor size and pathological type.Methods We collected data from the 912 primary breast cancer cases who had not undergone adjuvant therapy.The expression of c-erbB-2 was measured by immunohistochemistry（IHC）.Then we analyzed the correlation of c-erbB-2 expression with age,tumor size,clinical staging,tumor site,menopause status,axillary lymph node,ER,PR and pathological classification as well as the connection between c-erbB-2 expression and prognosis in using follow-up data.Results The total positive rate of c-erbB-2 was 23.0%.There were significant differences in c-erbB-2 expression among different age groups（P=0.009）,especially between those under 35 years old and those above 55 years old（P=0.006）;tumor diameter 〈2cm,2-5cm and 〉5cm groups（P〈0.01）,with the positive rate increased with tumor diameter;axillary lymph node metastasis（0）,（1-3）,（〉3） groups,the last one higher than the other two.The positive expression rate of c-erbB-2 was significantly higher in ER and PR positive groups than in ER and PR negative groups（P〈0.05）.The positive expression rate of c-erbB-2 was significantly higher in TMN stage Ⅲ group than in the other two groups（P〈0.05）.However,no significant differences were found in pathological classification,menopause status or tumor site groups（P〉0.05）.As for prognosis,the disease-free survival in c-erbB-2（＋） group was shortly that in c-erbB-2（-） group.Conclusion The overexpression of c-erbB-2 is positively correlated with tumor size,axillay lymphatic metastasis and clinical staging but negatively correlated with age,ER and PR.It is not correlated with menopause status,tumor site or pathological classification.c-erbB-2 can be used as an independent indicator for the prognosis of patients with breast cancer.

关 键 词：乳腺癌 C-ERBB-2 雌激素受体 孕激素受体 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]