高频重复经颅磁刺激治疗帕金森病临床疗效观察  

Clinicalal study of treating Parkinson's disease by repetitively transcranial magnetic stimulation

作　　者：于苏文[1] 郑秀琴[1] 陈红霞[1] 崔红霞[1] 蒋建波[1] 

机构地区：[1]解放军102医院神经内科,江苏常州213003

出　　处：《东南国防医药》2010年第2期109-111,共3页Military Medical Journal of Southeast China

摘　　要：目的分析高频重复经颅磁刺激(rTMS)对帕金森病(PD)的治疗作用及机理。方法35例PD患者接受rTMS治疗,采用帕金森病统一评分量表(UPDRS)评分、运动诱发电位(MEP)检查等评价疗效。结果治疗结束后UPDRS总分及Ⅰ、Ⅱ和Ⅲ分较治疗前均显著降低(均P<0.01),1分钟平均运动次数显著增加(P<0.01),行走速度显著增快(P<0.01),运动诱发电位静息阈值增高、潜伏期及皮质静息期延长(P<0.01)。1个月随访时仍较治疗前有统计学意义(P<0.01)。结论高频rTMS可以改善近期PD患者的临床症状,提高患者生活质量。Objective To study the efficacy and safety of treating Parkinson＇s disease （PD） by high frequency repetitively transcranial magnetic stimulation （rTMS）. Methods 35 patients with PD re- ceived rTMS therapy. The efficacy was assessed by UPDRS score and motion evoked potentials （MEP）. Resuits In rTMS treatment group, the UPDRS total scores, UPDRS I , Ⅱ and Ⅲ were significantly decreased after treatment comparing with that of pre-treatment （all P 〈 0.01 ）. The mean motion numbers of timed mo- tion test were significantly increased （P 〈 0.01 ）. MEP relaxed motion threshold was elevated, cortical la- tency and cortical silent period were prolonged （ P 〈 0.01 ）. There was significant differences after 1 months when follow-up （ P 〈 0.01 ）. Conclusion High frequency rTMS may improve the symptoms of the patients with PD and raise their quality of life.

关 键 词：帕金森病 重复经颅磁刺激 运动诱发电位 

分 类 号：R742.5[医药卫生—神经病学与精神病学]