脑缺血患者微栓子检测与黏附分子的相关性研究  

Association between microembolic signals and adhesion molecules in patients with cerebral ischemia

作　　者：隋艳玲[1] 潘旭东[1] 马爱军[1] 伊帅[1] 王琨[1] 

机构地区：[1]青岛大学医学院附属医院东区神经科,山东青岛266100

出　　处：《中风与神经疾病杂志》2010年第4期345-348,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的研究脑缺血患者微栓子与黏附分子的相关性。方法选择108例研究对象,其中68例为发病72h内颈内动脉或大脑中动脉区域脑梗死或短暂性脑缺血发作患者,经TCD检测微栓子信号(microembolic sig-nals,MES)分为MES阳性组(19例)和MES阴性组(49例);对照组40例,无脑梗死或脑缺血发作病史,且无明显颅内外动脉狭窄。均用双抗体夹心酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)测定血清可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1sICAM-1)、可溶性血管细胞黏附分子-1(soluble vascularcell adhesion molecule-1,sVCAM-1)水平。结果MES阳性组sICAM-1、sVCAM-1水平高于MES阴性组(P<0.05);MES阳性组、MES阴性组sICAM-1、sVCAM-1水平明显高于对照组(P<0.01)。结论黏附分子参与了脑缺血的损伤过程,且与动脉粥样硬化(artherosclerosis,AS)斑块的不稳定性相关。微栓子和黏附分子是发生脑梗死的危险因素。Objective To investigate the relationship between microembolic signals and adhesion molecules in patients with cerebral ischemia.Methods 108 patients were enrolled.We performed transcranial Doppler monitoring to detect microembolic signals（MES）in 68 patients with cerebral infarction or transient ischemic attack（TIA）within 72 hours by stenosis of internal carotid artery or middle cerebral artery.Then the 68 patients were divided into two groups：MES negative group（49）and MES positive group（19）.The other 40 cases（control group）had no histories of cerebral vascular diseases or stenosis of intracranial or extracranial arteries.Serum soluble adhesion molecules levels were measured by ELISA assay and were compared between every two groups.Results Serum soluble adhesive molecules levels were higher in MES positive group than in MES negative group（P0.05）.The levels in MES negative group and MES positive group were higher than the control group（P0.01）.Conclusions Adhesion molecules play important roles in the pathogenesis of ischemic cerebrovascular injury and associate with the instability of plaques.Microembolic signals and adhesion molecules are risk factors for ischemic cerebrovascular disorders.

关 键 词：脑缺血 微栓子信号 黏附分子 

分 类 号：R743.3[医药卫生—神经病学与精神病学]