外周血LFA-1和ICAM-1在非小细胞肺癌中的临床意义及表达  

Expression of LFA-1and ICAM-1 in non-small cell lung cancer and its clinical significance

作　　者：王凤玲[1] 黄佳滨[1] 

机构地区：[1]佳木斯大学附属第一医院老年病二科,黑龙江佳木斯154003

出　　处：《黑龙江医药科学》2010年第2期8-9,共2页Heilongjiang Medicine and Pharmacy

基　　金：佳木斯大学科研计划项目代码:040350

摘　　要：目的:探讨非小细胞肺癌血清中LFA-1和ICAM-1的表达在肿瘤侵袭转移过程中的作用机制。方法:采用双抗体夹心ABC-EL ISA法测定。结果:(1)非小细胞肺癌患者血清中LFA-1和ICAM-1的含量明显高于对照组;差异具有显著性(P<0.01);(2)非小细胞肺癌患者LFA-1和ICAM-1间存在正相关性(P<0.05)。(3)肺癌的Ⅲ+Ⅳ期与Ⅰ+Ⅱ期相比血清LFA-1、ICAM-1均有显著差异(P<0.05)。(4)有淋巴结转移者血清LFA-1和ICAM-1含量较无淋巴结转移者增高,差异显著(P<0.05)。结论:LFA-1 ICAM-1可能是反映肺癌侵袭转移潜能的一个有效生物学指标。Objective：To investigate the action mechanism of the serum LFA-1 and ICAM-1 expression in tumor invasion and metastasis in non-small cell lung cancer. Methods ：The total serum LFA-1 and ICAM levels were measured by ABC- ELISA. Resuits： （1） The serum LFA - land ICAM- 1 levels in non- small cell Lung cancer were significantly higher than those of the normal control group （P 〈 0. 01）. （2）There was a positive correlation between the serum LFA- 1 level and the serum ICAM- 1 level in the lung cancer group （P 〈0.05）. （3）The serum LFA-land ICAM-1 levels in the group of Terms Ⅲ and IV of lung cancer were significantly higher than those of the group of Terms Ⅰ and Ⅱ of lung cancer （P 〈 0. 05）. （4）The serum levels of LFA-land ICAM-1 in lymph node metastasis were significantly higher than those without lymph node metastasis （P 〈 0. 05 ）. Conclusion ：The LFA-land ICAM-1 might be valuable markers for assessing invasion and metastasis potential in lung cancer

关 键 词：淋巴细胞功能相关抗原-1 细胞间黏附分子-1 肺癌 

分 类 号：R734.2[医药卫生—肿瘤]