喹硫平与氟西汀治疗抑郁焦虑共病的对照研究  

Comparative study of quetiapine versus fluoxetine in the treatment of comorbid anxiety and depression

作　　者：支胜利[1] 尹析凡[1] 徐哲[1] 

机构地区：[1]湖州市第三人民医院,313000

出　　处：《上海精神医学》2010年第2期78-80,共3页Shanghai Archives of Psychiatry

摘　　要：目的探讨喹硫平与氟西汀对抑郁焦虑障碍共病的疗效和安全性。方法收集抑郁焦虑障碍共病的患者80例,分为喹硫平组和氟西汀组各40例,疗程8周。使用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)评定疗效,以治疗中出现的症状量表(TESS)评定不良反应。结果喹硫平组有38例、氟西汀组有37例完成8周的研究。治疗8周2组HAMD和HAMA量表减分率无统计学差异,治疗1周末喹硫平组疗效优于氟西汀组。治疗8周后喹硫平组有效率为89.5%(34/38),氟西汀组为89.2%(33/37)。喹硫平组无转躁患者,氟西汀组1例转躁。喹硫平组头晕的发生率明显多于氟西汀组。结论喹硫平单药治疗抑郁焦虑障碍共病的疗效与氟西汀相当,喹硫平组头晕者较多。Objective：To examine efficacy and safety of quetiapine versus fluoxetine in the treatment of comorbid depression and anxiety.Methods：80 patients with comorbid depression and anxiety were assigned equally into quetiapine group and fluoxetine group.The course of treatment was 8 weeks.Hamilton depression scale（HAMD） and Hamilton anxiety scale（HAMA） were applied to evaluate efficacy,and treatment emergent symptoms scale（TESS） was applied to evaluate side-effects of drugs.Results：Efficacy was comparable between the two groups.No significant difference was found between the two groups on reduction of HAMD and HAMA scores at the end of week 8（P〉0.05）.At the end of week 1,efficacy was superior in quetiapine group than in fluoxetine group（P〈0.05）.Response was found in 34（89.5%） patients in quetiapine group and 33（89.2%） patients in fluoxetine group at the end of 8-week treatment.None of the patient receiving quetiapine switched into mania,while 1 patients did so in fluoxetine group.Patients in quetiapine group were more likely to have dizziness than those in fluoxetine group.Conclusion：Efficacy was almost comparable between quetiapine and fluoxetine monotherapy.Dizziness was more frequent in quetiapine group.

关 键 词：喹硫平 抑郁焦虑共病 氟西汀 

分 类 号：R749.4[医药卫生—神经病学与精神病学]