乙型/丙型肝炎病毒相关性肝细胞癌450例分析  

Analysis of 450 patients with hepatocellular carcinoma associated with hepatitis B virus and/or hepatitis C virus

作　　者：谭炳芹[1] 王昌源[1] 杜磊[1] 张立华[1] 董格峰[1] 

机构地区：[1]山东大学医学院济南市传染病医院,山东济南250021

出　　处：《中国病原生物学杂志》2010年第4期293-295,共3页Journal of Pathogen Biology

基　　金：济南市科技局资助项目(济科合200807033-1)

摘　　要：目的比较乙型/丙型肝炎病毒(HBV/HCV)相关性肝细胞癌(HCC)的特点,探讨HCC发生的相关因素。方法收集2005年1月～2009年7月济南市传染病医院450例确诊的HCC住院患者病史及血清学资料,建立数据库,应用SPSS16.0软件进行统计分析。结果450例HCC患者HBV、HCV、HBV合并HCV感染分别为422、17例和11例。422例HBV感染者平均年龄(53.85±10.00)岁,高发年龄为50～59岁,男女比例为7.79∶1;17例HCV感染者平均年龄(60.18±5.47)岁,高发年龄为60～69岁,男女比例为2.40∶1。HCV相关性HCC(C-HCC)患者的发病年龄高于HBV相关性HCC(B-HCC)患者;B-HCC男性患者比例高于C-HCC;高病毒载量及长期肝炎发作是HCC形成的相关因素;C-HCC患者中2型糖尿病比例高于B-HCC患者。结论HBV感染所致的肝炎较HCV所致的肝炎更容易发生HCC。年龄大、男性、肝炎史长、肝硬化是HBV/HCV相关性HCC的主要相关因素。Objective To compare the characteristics of hepatitis-B-virus-related hepatocellular carcinoma（B-HCC）with hepatitis-C-virus-related hepatocellular carcinoma（C-HCC）and to explore factors related to the development of hepatocellular carcinoma（HCC）.Methods Records of patients hospitalized for HCC from January 2005 to July 2009 were reviewed.Case histories and serology information were collected,and a database was established and analyzed with SPSS16.0 software.Results Of 450 patients with HCC,422 had B-HCC,17 had C-HCC,and 11 had HBV/HCV co-infection.The mean age of the 422 patients with B-HCC was 53.85±10.00 years with a peak at 50-59 years of age.The mean age of the 17 patients with C-HCC was 60.18±5.47 years with a peak at 60-69 years of age.The male：female ratio for B-HCC and C-HCC patients was 7.79∶1 and 2.40∶1,respectively.The age of C-HCC onset was older than that of B-HCC,but the male：female ratio was lower.Both a high viral load and long-standing bouts of hepatitis were risk factors for HCC.The incidence of type 2 Diabetes Mellitus was higher in patients with C-HCC than in those with B-HCC.Conclusion HBV infection more readily developed into HCC than HCV infection.Being older,male,having a history of hepatitis,and liver cirrhosis were major risk factors for the development of HCC in patients infected with HBV and HCV.

关 键 词：肝炎病毒 乙型 肝炎病毒 丙型 肝细胞癌 相关因素 

分 类 号：R735.7[医药卫生—肿瘤] R373.21[医药卫生—临床医学]