血管痉挛性头痛舌下含化硝酸甘油的脑血流改变  

Effect of the cerebral blood flow in patients of vascular headache treat with sublingual administration of nitroglycerin

作　　者：刘济英[1] 侯军[1] 

机构地区：[1]山东省青岛市市立医院,山东青岛266011

出　　处：《中国当代医药》2010年第11期27-28,共2页China Modern Medicine

摘　　要：目的:探讨血管痉挛性头痛舌下含化硝酸甘油(nitroglycerin,NG)的脑血流改变。方法:通过经颅多普勒超声(transcranial dopple ultrasound,TCD)对40例正常人(Ⅰ组)和90例血管痉挛性头痛患者(Ⅱ组)的颅底动脉血流速度值及频谱形态进行对比分析。结果:含化NG1min时,Ⅱ组血流速度值高于Ⅰ组,2min后才开始减慢,并且出现血流速度最低值的时间早于Ⅰ组。两组血流速度值经t检验比较,差异有统计学意义(P<0.05);两组血流频谱形态均在含化NG1min即发生改变。结论:应用此药物试验可以动态观察脑血管的血流速度值及弹性情况。Objective：To investigate the effect of the cerebral blood flow in patients of vascular headache treat with sublingual administration of nitroglycerin（NG）.Methods：To compare and analyse the blood flow speed and spectra appearance in the arteries of base of skull obtained by using transcranial dopple ultrasound（TCD） of the 40 cases（group Ⅰ） and 90 patients of vascular headache（group Ⅱ）.Results：Blood flow speed in group Ⅰ was faster than that of group Ⅱ at 1 minute.Blood flow speed slowed down at 2 minutes,and the degree in group Ⅱ was more than group Ⅰ.There was significant difference between two groups.The spectra appearance in two groups had changed one minute after sublingual administration of nitroglycerin.Conclusion：Sublingual administration of nitroglycerin may change the cerebral blood flow.

关 键 词：经颅多普勒 硝酸甘油 血流速度值 血管弹性 血管痉挛性头痛 

分 类 号：R747.2[医药卫生—神经病学与精神病学]